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The Influence of the Media on a Leader's Image During the COVID-19 Pandemic: Th...
Bacalhau, Patrícia; Paulino, Raquel; Almeida, Sandra; Santos, Renato Pessoa dosThe media plays a pivotal role in disseminating information in contemporary society. In this regard, the undeniable influence of the media on a leader's image, particularly in times of crisis, is evident. This article aims to comprehensively analyze this influence, especially, through the analysis of the perceptions of the participants in this study, both military and civilian, of Admiral Gouveia e Melo's image...
In silico, NMR and pharmacological evaluation of an hydroxyoxindole cholinester...
Bacalhau, Patrícia; Fernandes, Luís; Martins, M. Rosário; Candeias, Fátima; Carreiro, Elisabete P.; Caldeira, A.Teresa; Guedes, Rita C.From a screening study of various potential inhibitors for cholinesterases (ChEs), compound (rac)-1 (4-((3-hydroxy-2-oxo-3-phenylindolin-1-yl) methyl) piperidin-1-ium chloride) showed an IC50 of 18 μM for butyrylcholinesterase (BuChE). Herein we present a toxicological and pharmacological evaluation of (rac)-1 to determine its potential for use as an alternative ChE inhibitor for the treatment of Alzheimer’s di...
New cholinesterase inhibitors for Alzheimer's disease: Structure Activity Studi...
Bacalhau, Patrícia; Amor, A. San Juan; Marques, Carolina S.; Peixoto, Daniela; Goth, Albertino; Guarda, Cátia; Silva, Mara; Arantes, SílviaA library of isoquinolinone and azepanone derivatives were screened for both acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) activity. The strategy adopted included (a) in vitro biological assays, against eel AChE (EeAChE) and equine serum BuChE (EqBuChE) in order to determine the compounds IC50 and their dose-response activity, consolidated by (b) molecular docking studies to evaluate the docking...