5 documents found, page 1 of 1
Therapeutic Potential of Resveratrol for Glioma: A Systematic Review and Meta-A...
Luís, Ângelo; Marcelino, Helena; Domingues, F.C.; Pereira, L.; Cascalheira, JoséGliomas are aggressive malignant brain tumors, with poor prognosis despite available therapies, raising the necessity for finding new compounds with therapeutic action. Numerous preclinical investigations evaluating resveratrol’s anti-tumor impact in animal models of glioma have been reported; however, the variety of experimental circumstances and results have prevented conclusive findings about resveratrol’s e...
Adenosine inhibits cell proliferation differently in human astrocytes and in gl...
Marcelino, Helena; Carvalho, Tiago M. A.; Tomás, Joana; Teles, Francisca I.; Honório, Ana C.; Rosa, Carolina B.; Costa, Ana R.; Costa, Bruno M.Glioblastoma (GBM) is the most common brain primary tumour. Hypoxic regions in GBM are associated to tumour growth. Adenosine accumulates in hypoxic regions and can affect cell proliferation and survival. However, how proliferating GBM cells respond/adapt to increased adenosine levels compared to human astrocytes (HA) is not clarified and was addressed in the present work. GBM cell lines and HA were treated for...
The effects of cannabinoids on glioblastoma growth: A systematic review with me...
Luís, Ângelo; Marcelino, Helena; Rosa, Carolina Boialvo; Domingues, F.C.; Pereira, L.; Cascalheira, JoséGlioblastoma multiforme (GBM) is the most frequent and aggressive malignant brain tumour, with a poor prognosis despite available surgical and radio-chemotherapy, rising the necessity for searching alternative therapies. Several preclinical studies evaluating the efficacy of cannabinoids in animal models of GBM have been described, but the diversity of experimental conditions and of outcomes hindered definitive...
Adenosine inhibits human astrocyte proliferation independently of adenosine rec...
Marcelino, Helena; Nogueira, Vanda Cristina Simões; Santos, Cecilia; Quelhas, Patricia; Carvalho, Tiago; Gomes, João Fonseca; Tomás, JoanaBrain adenosine concentrations can reach micromolar concentrations in stressful situations such as stroke, neurodegenerative diseases or hypoxic regions of brain tumours. Adenosine can act by receptor-independent mechanism by reversing the reaction catalysed by S-adenosylhomocysteine (SAH) hydrolase, leading to SAH accumulation and inhibition of S-adenosylmethionine (SAM)-dependent methyltransferases. Astrocyte...
Analysis of the effects of sex hormone background on the rat choroid plexus tra...
Quintela, Telma; Gonçalves, Isabel; Carreto, Laura C.; Santos, Manuel A. S.; Marcelino, Helena; Patriarca, Filipa M.; Santos, Cecília R. A.The choroid plexus (CP) are highly vascularized branched structures that protrude into the ventricles of the brain, and form a unique interface between the blood and the cerebrospinal fluid (CSF), the blood-CSF barrier, that are the main site of production and secretion of CSF. Sex hormones are widely recognized as neuroprotective agents against several neurodegenerative diseases, and the presence of sex hormon...