5 documents found, page 1 of 1
Introducing the OECD guidance document on occupational biomonitoring
Hopf, Nancy B.; Bessems, Jos; Santonen, Tiina; Viegas, Susana; Casteleyn, Ludwine; Poddalgoda, Devika; Lamkarkach, Farida; Göen, ThomasPublisher Copyright: © 2024 The Authors; Derivation of occupational biomonitoring levels (OBLs) is needed to effectively utilize biomonitoring for assessing exposures to chemical substances, and consequently, implement risk reduction measures to reduce health risks among workers. OBLs are the appropriate option for chemical substances that can be absorbed through the skin. This methodology for derivation of OBL...
Guidance on minimum information requirements (MIR) from designing to reporting ...
Zare Jeddi, Maryam; Galea, Karen S.; Ashley-Martin, Jillian; Nassif, Julianne; Pollock, Tyler; Poddalgoda, Devika; Kasiotis, Konstantinos M.Funding Information: We would like to thank all the experts active in the International Society for Exposure Science (ISES) European Regional Chapter, working group on Human biomonitoring (ISES Europe HBM working group) and the HBM Global Network for their support and contributions. Additionally, special thanks to ECETOC for supporting this initiative and development of www.FAIREHR.com platform. Ethical approva...
FAIREHR
Galea, Karen S.; Brooker, Finlay; Rashid, Shahzad; Bader, Michael; Bamai, Yu Ait; Bessems, Jos; Beyene, Embialle Mengistie; Connolly, AlisonFunding Information: The development of the online FAIREHR platform was supported by ECETOC (European Centre for Ecotoxicology and Toxicology of Chemicals). Publisher Copyright: © The Author(s) 2025.; The FAIREHR (Findable, Accessible, Interoperable, Reusable Environmental and Health Registry) platform is a state-of-the-art online registry for prospective harmonization of human biomonitoring (HBM). It was devel...
A harmonized occupational biomonitoring approach
Hopf, Nancy B.; Rousselle, Christophe; Poddalgoda, Devika; Lamkarkach, Farida; Bessems, Jos; Schmid, Kaspar; Jones, Kate; Takaki, KokiPublisher Copyright: © 2024; Biomonitoring has been widely used in assessing exposures in both occupational and public health complementing chemical risk assessments because it measures the concentrations of chemical substances in human body fluids (e.g., urine and blood). Biomonitoring considers all routes and sources of exposure. An occupational biomonitoring guidance document has been elaborated (OECD Occupa...
The caffeine-binding adenosine A(2A) receptor induces age-like HPA-axis dysfunc...
Batalha, Vania L; Ferreira, Diana G; Coelho, Joana E.; Valadas, Jorge S; Gomes, Rui; Temido-Ferreira, Mariana; Shmidt, Tatiana; Baqi, Younis; Buee, LucCaffeine is associated with procognitive effects in humans by counteracting overactivation of the adenosine A(2A) receptor (A(2A)R), which is upregulated in the human forebrain of aged and Alzheimer's disease (AD) patients. We have previously shown that an anti-A(2A)R therapy reverts age-like memory deficits, by reestablishment of the hypothalamic-pituitary-adrenal (HPA) axis feedback and corticosterone circadi...