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Contemporary and historical human migration patterns shape hepatitis B virus di...

Potter, Barney I.; Thijssen, Marijn; Trovão, Nídia Sequeira; Pineda-Peña, Andrea; Reynders, Marijke; Mina, Thomas; Alvarez, Carolina

Funding Information: BIP and GB acknowledge support from the Internal Funds KU Leuven (Grant No. C14/18/094). GB acknowledges support from the Research Foundation—Flanders (‘Fonds voor Wetenschappelijk Onderzoek—Vlaanderen’, G0E1420N, G098321N). PL acknowledges support from the Research Foundation—Flanders (‘Fonds voor Wetenschappelijk Onderzoek—Vlaanderen’, G0D5117N, G0B9317N, G051322N). The opinions expressed...


Reconstruction of the origin and dispersal of the worldwide dominant Hepatitis ...

Trovão, Nídia Sequeira; Thijssen, Marijn; Vrancken, Bram; Pineda-Peña, Andrea Clemencia; Mina, Thomas; Amini-Bavil-Olyaee, Samad; Lemey, Philippe

Funding Information: N.S.T. and P.L. were supported by the European Union Seventh Framework Programme [FP7/2007-2013] under Grant Agreement number 278433-PREDEMICS. The research leading to these results has received funding from the European Research Council under the European Union's Horizon 2020 research and innovation programme (grant agreement no. 725422 - ReservoirDOCS). MT is a PhD fellow at the Research ...


Genome-Wide Diversity of Zika Virus

Seabra, Sofia G; Libin, Pieter J. K.; Theys, Kristof; Zhukova, Anna; Potter, Barney I; Nebenzahl-guimaraes, Hanna; Gorbalenya, Alexander E

The Zika virus (ZIKV) disease caused a public health emergency of international concern that started in February 2016. The overall number of ZIKV-related cases increased until November 2016, after which it declined sharply. While the evaluation of the potential risk and impact of future arbovirus epidemics remains challenging, intensified surveillance efforts along with a scale-up of ZIKV whole-genome sequencin...


PhyloGeoTool

Libin, Pieter; Vanden Eynden, Ewout; Incardona, Francesca; Nowé, Ann; Bezenchek, Antonia; Sönnerborg, Anders; Vandamme, Anne-Mieke; Theys, Kristof

Funding Information: The authors thank the EuResist Network (www.euresist.org) for providing data and the reviewers for their insightful comments which improved both the manuscript and PhyloGeoTool software. Funding Information: This work was supported by EucoHIV (www.eucohiv.org). K.T. is funded as a Postdoctoral Researcher by the Research Foundation \u2013 Flanders (FWO). P.L. is funded by a doctoral grant of...


Quantifying next generation sequencing sample pre-processing bias in HIV-1 comp...

Vrancken, Bram; Trovão, Nídia Sequeira; Baele, Guy; Van Wijngaerden, Eric; Vandamme, Anne Mieke; van Laethem, Kristel; Lemey, Philippe

Genetic analyses play a central role in infectious disease research. Massively parallelized “mechanical cloning” and sequencing technologies were quickly adopted by HIV researchers in order to broaden the understanding of the clinical importance of minor drug-resistant variants. These efforts have, however, remained largely limited to small genomic regions. The growing need to monitor multiple genome regions fo...


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