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The Impact of Donor Risk Index, Recipients’ and Operative Characteristics on Po...

Cardoso, FS; Bagulho, L; Coelho, JS; Lamelas, J; Mateus, E; Mendes, M; Glória, H; Ribeiro, V; Mega, R; Pena, A; Pinto Marques, H; Germano, N; Nolasco, F

Background and Aims: The donor risk index (DRI) quantifies donor-related characteristics potentially associated with increased risk of early graft failure. We aimed to assess the impact of the DRI, recipient and perioperative factors on post liver transplant (LT) outcomes. Methods: This was a singlecenter retrospective cohort study including all adult (≥18 years) patients who underwent LT from 01/2019 to 12/201...


Alcohol Consumption Post-Liver Transplantation: a Cross-Sectional Study

Chálim Rebelo, C; Félix, C; Sousa Cardoso, F; Bagulho, L; Sousa, M; Mendes, M; Glória, H; Mateus, É; Mega, I; Jara, M; Pinto Marques, H; Nolasco, F

Background: Listing patients with alcohol-associated liver disease (ALD) for liver transplant (LT) remains challenging especially due to the risk of alcohol resumption post-LT. We aimed to evaluate post-LT alcohol consumption at a Portuguese transplant center. Methods: We conducted a cross-sectional study including LT recipients from 2019 at Curry Cabral Hospital, Lisbon, Portugal. A pretested survey and a vali...


Positive Fluid Balance Was Associated with Mortality in Patients with Acute-on-...

Sousa Cardoso, F; Pereira, R; Laranjo, A; Gamelas, V; Bagulho, L; Germano, N; Karvellas, C

Purpose: We aimed to study the effect of FB in the outcomes of critically-ill patients with cirrhosis. Materials: Retrospective analysis of all adult consecutive admissions of patients with cirrhosis and organ failures to the Intensive Care Unit (ICU) at Curry Cabral Hospital (Lisbon, Portugal) and University of Alberta Hospital (Edmonton, Canada) on 08/2013-08/2017. Primary exposure was FB at 3 and 7 days post...


Acute-on-Chronic Liver Failure Syndrome - Clinical Results from an Intensive Ca...

Pereira, R; Bagulho, L; Sousa Cardoso, F

Objective: To characterize a cohort of acute-on-chronic liver failure patients in Intensive Care and to analyze the all-cause 28-day mortality risk factors assessed at ICU admission and day 3. Methods: This was a retrospective cohort study of consecutive patients admitted to the intensive care unit between March 2013 and December 2016. Results: Seventy-one patients were included. The median age was 59 (51 - 64)...


Lactate and Number of Organ Failures Predict Intensive Care Unit Mortality in P...

Sousa Cardoso, F; Abraldes, J; Sy, E; Ronco, JJ; Bagulho, L; Mcphail, M; Karvellas, C

Background and aims: Patients with acute-on-chronic liver failure (ACLF) have high mortality rates. Most prognostic scores were not developed for the intensive care unit (ICU) setting. We aimed to improve risk stratification for patients with ACLF in the ICU. Methods: A training set with 240 patients with cirrhosis and organ failures (Chronic Liver Failure Sequential Organ Failure Assessment score [CLIF-SOFA]) ...


Acute-on-Chronic Liver Failure: A Portuguese Single-Center Reference Review

Verdelho, M; Perdigoto, R; Machado, J; Mateus, É; Marcelino, P; Pereira, R; Fortuna, P; Bagulho, L; Bento, L; Ribeiro, F; Nolasco, F; Martins, A

Acute-on-chronic liver failure (ACLF) is a syndrome characterized by an acute deterioration of a patient with cirrhosis, frequently associated with multi-organ failure and a high short-term mortality rate. We present a retrospective study that aims to characterize the presentation, evolution, and outcome of patients diagnosed with ACLF at our center over the last 3 years, with a comparative analysis between the...


Uma causa rara de insuficiência hepática aguda fulminante num jovem adulto

Alexandrino, G; Bernardo, S; Bagulho, L; Marcelino, P; Lopes, V

A existência de alterações ligeiras nas provas hepáticas é uma manifestação comum do golpe de calor. Geralmente, existe uma elevação transitória e assintomática das transaminases. No entanto, formas graves de insuficiência hepática aguda (IHA) são extremamente raras neste contexto. Descreve-se um caro raro de IHA fulminante induzida por golpe de calor. Trata-se de um rapaz de 20 anos, saudável, que colapsou sub...


Acute Liver Failure: An Up-To-Date Approach

Cardoso, FS; Marcelino, P; Bagulho, L; Karvellas, C

Acute liver failure is a rare but potentially devastating disease. Throughout the last few decades, acute liver failure outcomes have been improving in the context of the optimized overall management. This positive trend has been associated with the earlier recognition of this condition, the improvement of the intensive care unit management, and the developments in emergent liver transplantation. Accordingly, w...



Infections After Liver Transplantation: A Retrospective, Single-Center Study

Antunes, M; Teixeira, A; Fortuna, P; Moya, B; Martins, A; Bagulho, L; Pereira, JP; Bento, L; Perdigoto, R; Barroso, E; Marcelino, P

Objective. To access the incidence of infectious problems after liver transplantation (LT). Design. A retrospective, single-center study. Materials and Methods. Patients undergoing LT from January 2008 to December 2011 were considered. Exclusion criterion was death occurring in the first 48 hours after LT. We determined the site of infection and the bacterial isolates and collected and compared recipient’s vari...


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