60 documents found, page 1 of 6
Synergic effect of allopurinol in combination with nitro-heterocyclic compounds...
Mazzeti, Ana Lia; Diniz, Lívia de Figueiredo; Gonçalves, Karolina Ribeiro; WonDollinger, Ruan Schott; Martins, Tassiane Assíria Fontes; Ribeiro, IsabelaCombination therapy has gained attention as a possible strategy for overcoming the limitations of the present therapeutic arsenal for Chagas disease. The aim of this study was to evaluate the effect of allopurinol in association with nitroheterocyclic compounds on infection with the Y strain of Trypanosoma cruzi. The in vitro effect of allopurinol plus benznidazole or nifurtimox on intracellular amastigotes in ...
Leishmania infantum-derived lipophosphoglycan as an antigen in the accurate ser...
Portela, Ricardo Wagner Dias; Soares, Rodrigo Pedro Pinto; Porfírio Passos, Gabriela; Larangeira, Daniela Farias; Barral, Thiago Assis DoriaLipophosphoglycan (LPG) is the major surface glycoconjugate of Leishmania protozoan and has an important biological role in host-parasite interactions both in the midgut epithelium of the sand fly vector and in the vertebrate macrophages. Canine leishmaniasis (CanL) is a chronic infectious disease predominantly caused by Leishmania infantum. An early and accurate immunodiagnosis of the disease is crucial for ve...
Echocardiographic measurements in a preclinical model of chronic chagasic cardi...
Carvalho, Eduardo Butturini de; Ramos, Isalira Peroba Rezende; Nascimento, Alvaro Fernando da Silva do; Brasil, Guilherme Visconde; Mello, Debora BastosBackground: The failure to translate preclinical results to the clinical setting is the rule, not the exception. One reason that is frequently overlooked is whether the animal model reproduces distinctive features of human disease. Another is the reproducibility of the method used to measure treatment effects in preclinical studies. Left ventricular (LV) function improvement is the most common endpoint in precl...
Mir-190b negatively contributes to the Trypanosoma cruzi-infected cell survival...
Monteiro, Cintia Junia; Antunes Mota, Suianne Leticia; Diniz, Livia de Figueiredo; Bahia, Maria Terezinha; Moraes, Karen C. M. [UNESP]Made available in DSpace on 2018-11-26T16:19:07Z (GMT). No. of bitstreams: 0 Previous issue date: 2015-12-01. Added 1 bitstream(s) on 2019-10-09T18:25:47Z : No. of bitstreams: 1 S0074-02762015000800996.pdf: 415736 bytes, checksum: 2920e86bd4a6af99ec226211810d7a5d (MD5); Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); UFOP; ...
Ravuconazole self-emulsifying delivery system : in vitro activity against Trypa...
Spósito, Pollyanna Álvaro; Mazzeti, Ana Lia; Faria, Caroline de Oliveira; Urbina, Julio Alberto; Lana, Gwenaelle Elza Nathalie PoundSelf-emulsifying drug delivery systems (SEDDSs) are lipid-based anhydrous formulations composed of an isotropic mixture of oil, surfactant, and cosurfactants usually presented in gelatin capsules. Ravuconazole (Biopharmaceutics Classification System [BCS] Class II) is a poorly water-soluble drug, and a SEDDS type IIIA was designed to deliver it in a predissolved state, improving dissolution in gastrointestinal ...
Trypanosoma cruzi nucleoside triphosphate diphosphohydrolase 1 (TcNTPDase-1) bi...
Mariotini-Moura, Christiane; Bastos, Matheus Silva e; Castro, Felipe Freitas de; Trindade, Mellina Lanna; Vasconcellos, Raphael de SouzaPrevious work has suggested that Trypanosoma cruzi diphosphohydrolase 1 (TcNTPDase-1) may be involved in the infection of mammalian cells and serve as a potential target for rational drug design. In this work, we produced recombinant TcNTPDase-1 and evaluated its nucleotidase activity, cellular localization and role in parasite adhesion to mammalian host cells. TcNTPDase-1 was able to utilize a broad range of t...
Recombinant Leishmania (Leishmania) infantum Ecto-Nucleoside Triphosphate Dipho...
Souza, Ronny Francisco de; Santos, Yaro Luciolo dos; Vasconcellos, Raphael de Souza; Borges-Pereira, Lucas; Almeida, Márcia Rogéria deCanine visceral leishmaniasis is an important public health concern. In the epidemiological context of human visceral leishmaniasis, dogs are considered the main reservoir of Leishmania parasites; therefore, dogs must be epidemiologically monitored constantly in endemic areas. Furthermore, dog to human transmission has been correlated with emerging urbanization and increasing rates of leishmaniasis infection wo...
Pharmacological characterization, structural studies, and in vivo activities of...
Buckner, Frederick S.; Bahia, Maria Terezinha; Suryadevara, Praveen Kumar; White, Karen L.; Shackleford, David M.; Chennamaneni, Naveen KumarChagas disease, caused by the protozoan pathogen Trypanosoma cruzi, remains a challenging infection due to the unavailability of safe and efficacious drugs. Inhibitors of the trypanosome sterol 14 -demethylase enzyme (CYP51), including azole antifungal drugs, are promising candidates for development as anti-Chagas disease drugs. Posaconazole is under clinical investigation for Chagas disease, although the high ...
Variation in susceptibility to benznidazole in isolates derived from Trypanosom...
Veloso, Vanja Maria; Toledo, Max Jean de Ornelas; Lana, Marta de; Chiari, Egler; Tafuri, Washington Luiz; Bahia, Maria TerezinhaIn this work, the susceptibility to benznidazole of two parental Trypanosoma cruzi strains, Colombian and Berenice-78, was compared to isolates obtained from dogs infected with these strains for several years. In order to evaluate the susceptibility to benznidazole two groups of mice were infected with one of five distinct populations isolated from dogs as well as the two parental strains of T. cruzi. The first...
Chagas cardiomyopathy : the potential effect of benznidazole treatment on diast...
Santos, Fabiane Matos dos; Mazzeti, Ana Lia; Caldas, Sérgio; Gonçalves, Karolina Ribeiro; Lima, Wanderson Geraldo de; Torres, Rosália MoraisCardiac involvement represents the main cause of mortality among patients with Chagas disease, and therelevance of trypanocidal treatment to improving diastolic dysfunction is still doubtful. In the presentstudy, we used a canine model infected with the benznidazole-sensitive Berenice-78 Trypanosoma cruzistrain to verify the efficacy of an etiologic treatment in reducing the parasite load and ameliorating cardi...