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Accelerated Blood Clearance (ABC) phenomenon favors the accumulation of tartar ...
Lopes, Tamara Cristina Moreira; Silva, Débora Faria; Costa, Walyson Coelho; Frezard, Frederic Jean Georges; Barichello, José MarioTartar emetic (TE) was the first drug used to treat leishmaniasis.However, its use was discontinued due to high toxicity. Association of TE with liposomes is a strategy to reduce its side effects. Pegylated liposomes (Lpeg) present lower rates of uptake by macrophages and prolonged circulation compared to their nonpegylated counterparts. However, repeated administration of Lpeg can cause an Accelerated Blood Cl...
Anti-inflammatory and antinociceptive activities of Campomanesia adamantium.
Ferreira, Lidiane Cristina; Guimarães, Andrea Grabe; Paula, Carmem Aparecida de; Michel, Marcela Carolina de Paula; Guimarães, Raquel GomesEthnopharmacological relevance: Campomanesia species are used in folk medicine as anti-inflammatory, anti-rheumatic, anti-diarrheal and hypocholesterolemic. Aim of the study: The present study investigated the in vivo anti-inflammatory and antinociceptive properties of ethyl acetate (AE) and aqueous (Aq) extracts from leaves of Campomanesia adamantium and in vitro anti-inflammatory activity of AE and its isolated ...
Multicomponent LBSap vaccine displays immunological and parasitological profile...
Mendonça, Ludmila Zanandreis de; Resende, Lucilene Aparecida; Lanna, Mariana Ferreira; Soares, Rodrigo Dian de Oliveira Aguiar; Roatt, Bruno MendesBackground: In past years, many researchers have sought canine visceral leishmaniasis (CVL) prevention through the characterization of Leishmania antigens as vaccine candidates. Despite these efforts, there is still no efficient vaccine for CVL control. Methods: In the present study, we performed a pre-clinical vaccine trial using BALB/c mice to compare the effects of the multicomponent LBSap vaccine with those...
Association of liposome-encapsulated trivalent antimonial with ascorbic acid: a...
Castro, Renata Alves de Oliveira e; Barcellos, Neila Marcia Silva; Licio, Carolina Souza Andrade; Souza, Janine Braga deVisceral leishmaniasis (VL) is a chronic debilitating disease endemic in tropical and subtropical areas, caused by protozoan parasites of the genus Leishmania. Annually, it is estimated the occurrence of 0.2 to 0.4 million new cases of the disease worldwide. Considering the lack of an effective vaccine the afflicted population must rely on both, an accurate diagnosis and successful treatment to combat the disea...
Antigenic extracts of Leishmania braziliensis and Leishmania amazonensis associ...
Grenfell, Rafaella Fortini Queiroz; Silva, Eduardo de Almeida Marques da; Testasicca, Miriam Conceição de Souza; Coelho, Eduardo Antônio FerrazThis study evaluated two vaccine candidates for their effectiveness in protecting BALB/c mice against Leishma¬nia chagasi infection. These immunogenic preparations were composed of Leishmania amazonensis or Leishmania braziliensis antigenic extracts in association with saponin adjuvant. Mice were given three subcutaneous doses of one of these vaccine candidates weekly for three weeks and four weeks later challe...
Evaluation of immune responses and protection induced by A2 and nucleoside hydr...
Zanin, Francisca Helena Calheiros; Coelho, Eduardo Antônio Ferraz; Tavares, Carlos Alberto Pereira; Silva, Eduardo de Almeida Marques daSeveral antigens have been tested as vaccine candidates against Leishmania infections but controversial results have been reported when different antigens are co-administered in combined vaccination protocols. Immunization with A2 or nucleoside hydrolase (NH) antigens was previously shown to induce Th1 immune responses and protection in BALB/c mice against Leishmania donovani and L. amazonensis (A2) or L. donov...
Immune response to Leishmania (Leishmania) chagasi infection is reduced in maln...
Serafim, Tiago Donatelli; Malafaia, Guilherme; Silva, Marcelo Eustáquio; Pedrosa, Maria Lúcia; Rezende, Simone AparecidaProtein-energy malnutrition and micronutrient deficiencies may down-regulate immune response and increase morbidity and mortality due to infection. In this study, a murine model was used to study the effects of protein, iron and zinc deficiencies on the immune response to Leishmania (Leishmania) chagasi infection. Mice were initially fed a standard diet or with a diet containing 3% casein but deficient in zinc ...
Down modulation of MHC surface molecules on B cells by suppressive immune compl...
Rezende, Simone Aparecida; Gollob, Kenneth John; Oliveira, Rodrigo Corrêa de; Goes, Alfredo Miranda deGranulomatous inflammation around parasite eggs is the prominent lesion in human schistosomiasis. Studies have suggested the involvement of a series of suppressive mechanisms in the control of this reaction, such as macrophages, cytokines, idiotipic interactions and immune complexes (IC). The studies examine the role of IC obtained from chronic intestinal schistosomiasis patients (ISP) in the reactivity of peri...
Successful vaccination against Leishmania chagasi infection in BALB/c mice with...
Vilela, Márcia de Carvalho; Gomes, Daniel Cláudio de Oliveira; Silva, Eduardo de Almeida Marques da; Serafim, Tiago DonatelliThis study evaluated the potential of a Leishmania antigen vaccine in protecting BALB/c mice against Leishmania chagasi. Mice received two subcutaneous doses of L. amazonensis vaccine with Corynebacterium parvum and subsequent boost was done without adjuvant. One week later, mice were challenged with L. chagasi. We observed that this vaccine caused a significant reduction in parasite load in liver and spleen an...
Role of immune complexes from pacients with different clinical forms of Schisto...
Rezende, Simone Aparecida; Lambertucci, José Roberto; Goes, Alfredo Miranda deSchistosomiasis is a disease whose pathology is strongly related to the granulomatous reaction formed around parasite eggs trapped in host tissues. Studies have shown that the chronic intestinal form (INT) of this infection is associated with a variety of immunoregulatory mechanisms which lead to a diminished granulomatous reaction. Using an in vitro model of granuloma reaction, we show that immune complexes (I...