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The novel 5-lipoxygenase inhibitor (ABT-761) attenuates cerebral vasospasm in a...

Barbosa, MD; Arthur, AS; Louis, RH; Polin, R; Kassel, N

Date: 2004   |   Origin: Repositório do Centro Hospitalar e Universitário de Coimbra
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The novel 5-lipoxygenase inhibitor ABT-761 attenuates cerebral vasospasm in a r...

Barbosa, MD; Arthur, AS; Louis, RH; MacDonald, T; Polin, RS; Gazak, C; Kassell, NF

OBJECTIVE: Eicosanoids have been implicated in the pathogenesis of cerebral vasospasm after subarachnoid hemorrhage (SAH). Leukotrienes, 5-hydroxyperoxyeicosatetraenoic acid, and 5-hydroxyeicosatetraenoic acid are part of this group of substances, resulting from the 5-lipoxygenase activity on arachidonic acid metabolism. This study examined the effects of ABT-761, a new 5-lipoxygenase inhibitor, on cerebral vas...

Date: 2001   |   Origin: Repositório do Centro Hospitalar e Universitário de Coimbra
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