4 documents found, page 1 of 1
Circadian clock genes Bmal1 and Clock during early chick development
Gonçalves, Lisa; Vinhas, Maurícia; Pereira, Rui; Pais De Azevedo, Tomás; Bajanca, Fernanda; Palmeirim, IsabelBackground: The circadian clock is a well‐described temporal organizer in adult organisms. Despite the particularly evident need for temporal control during embryo development, the effect of environmental cues is still greatly neglected. Few studies have reported circadian clock gene expression in early embryonic stages. However, nothing is known about circadian clock gene expression and function in the first s...
Ataxin-3 plays a role in mouse myogenic differentiation through regulation of i...
Costa, Maria do Carmo; Bajanca, Fernanda; Rodrigues, Ana João; Tomé, Ricardo J.; Corthals, Gary; Ribeiro, Sandra Macedo; Paulson, Henry L.BACKGROUND: During myogenesis several transcription factors and regulators of protein synthesis and assembly are rapidly degraded by the ubiquitin-proteasome system (UPS). Given the potential role of the deubiquitinating enzyme (DUB) ataxin-3 in the UPS, and the high expression of the murine ataxin-3 homolog in muscle during embryogenesis, we sought to define its role in muscle differentiation. METHODOLOGY/PRIN...
Progressive mRNA decay establishes an mkp3 expression gradient in the chick lim...
Pascoal, Susana Alexandra Rodrigues; Andrade, Raquel P.; Bajanca, Fernanda; Palmeirim, IsabelThe apical ectodermal ridge (AER) controls limb outgrowth and patterning, such that its removal causes changes in mesodermal gene expression, cell death and limb truncation. Fibroblast growth factor (FGF) family members are expressed in the AER and can rescue limb bud outgrowth after AER removal. Cells localized underneath the AER are maintained in an undifferentiated state by the FGFs produced by the AER. MAPK...
Molecular clocks underlying vertebrate embryo segmentation: a 10-year-old hairy...
Andrade, Raquel P.; Palmeirim, Isabel; Bajanca, FernandaSegmentation of the vertebrate embryo body is a fundamental developmental process that occurs with strict temporal precision. Temporal control of this process is achieved through molecular segmentation clocks, evidenced by oscillations of gene expression in the unsegmented presomitic mesoderm (PSM, precursor tissue of the axial skeleton) and in the distal limb mesenchyme (limb chondrogenic precursor cells). The...