4 documents found, page 1 of 1
De novo design of potent and selective mimics of IL-2 and IL-15
Silva, Daniel-Adriano; Yu, Shawn; Ulge, Umut Y.; Spangler, Jamie B.; Jude, Kevin M.; Labão-Almeida, Carlos; Ali, Lestat R.; Quijano-Rubio, AlfredoWe describe a de novo computational approach for designing proteins that recapitulate the binding sites of natural cytokines, but are otherwise unrelated in topology or amino acid sequence. We use this strategy to design mimics of the central immune cytokine interleukin-2 (IL-2) that bind to the IL-2 receptor βγc heterodimer (IL-2Rβγc) but have no binding site for IL-2Rα (also called CD25) or IL-15Rα (also know...
Two years later: journals are not yet enforcing the ARRIVE guidelines on report...
Baker, David; Lidster, Katie; Sottomayor, Ana; Amor, SandraThere is growing concern that poor experimental design and lack of transparent reporting contribute to the frequent failure of pre-clinical animal studies to translate into treatments for human disease. In 2010, the Animal Research: Reporting of In Vivo Experiments (ARRIVE) guidelines were introduced to help improve reporting standards. They were published in PLOS Biology and endorsed by funding agencies and pu...
Researching the use of force: the background to the international project
Stenning, Philip; Birkbeck, Christopher; Adang, Otto; Baker, David; Feltes, Thomas; Gabaldón, Luis Gerardo; Haberfeld, Maki; Machado, Eduardo PaesTrabalho completo: acesso restrito, p.95–110; Submitted by Bruna Lessa (lessbruna@gmail.com) on 2012-07-06T19:57:10Z No. of bitstreams: 1 (110)fulltext.pdf: 229278 bytes, checksum: 580a9c5b72543156d90289ac70125e9a (MD5); Made available in DSpace on 2012-07-06T19:57:10Z (GMT). No. of bitstreams: 1 (110)fulltext.pdf: 229278 bytes, checksum: 580a9c5b72543156d90289ac70125e9a (MD5) Previous issue date: 2009; This ar...
Singing the same tune? International continuities and discontinuities in how po...
Waddington, P. A. J.; Adang, Otto; Baker, David; Birkbeck, Christopher; Feltes, Thomas; Gabaldón, Luis Gerardo; Machado, Eduardo Paes; Stenning, PhilipTrabalho completo: acesso restrito, p.111–138; Submitted by Bruna Lessa (lessbruna@gmail.com) on 2012-07-09T20:19:55Z No. of bitstreams: 1 (116)fulltext.pdf: 337888 bytes, checksum: 3f9270d63ce55539af55db33536c68f8 (MD5); Made available in DSpace on 2012-07-09T20:19:55Z (GMT). No. of bitstreams: 1 (116)fulltext.pdf: 337888 bytes, checksum: 3f9270d63ce55539af55db33536c68f8 (MD5) Previous issue date: 2009; This a...