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Interdependency between oxytocin and dopamine in trust-based learning in mice

Budniok, Samuel; Callaerts-Vegh, Zsuzsanna; Bakermans-Kranenburg, Marian; Bosmans, Guy; D’Hooge, Rudi

Oxytocin (OT) is a neuropeptide implicated in complex social behaviors such as trust and attachment, yet the neural mechanisms underlying its effects remain unclear. OT is thought to modulate behavior by enhancing salience of social cues and attenuating prediction error (PE) processing, the discrepancy between expected and actual outcomes that drives learning. Since both salience coding and PE processing involv...


Promoting socioemotional development in early childhood: implementation and eva...

Veríssimo, Manuela; Guedes, Maryse; Fernandes, Marilia; Fernandes, Carla; Santos, Carolina; Diniz, Eva; Oliveira, Paula; Negrão, Mariana

Background: The prevention of internalizing and externalizing behavioral problems in children is a critical scientific and public health priority. Research highlights maternal sensitivity—defined as a caregiver’s ability to perceive, interpret, and respond appropriately to their child’s cues—and consistent but non-coercive discipline as key factors in reducing these behavioral issues. The Video-feedback Interve...


Promoting socioemotional development in early childhood: Implementation and eva...

Verissimo, Manuela; Guedes, Maryse; Fernandes, Marilia; Fernandes, Carla; Santos, Carolina; Diniz, Eva; Oliveira, Paula; Negrão, Mariana

The prevention of internalizing and externalizing behavioral problems in children is a critical scientific and public health priority. Research highlights maternal sensitivity—defined as a caregiver’s ability to perceive, interpret, and respond appropriately to their child’s cues—and consistent but non-coercive discipline as key factors in reducing these behavioral issues. The Video-feedback Intervention to Pro...


Exploring associations between infant attachment, maternal sensitivity, and att...

Peltola, Mikko J.; Biro, Szilvia; Huffmeijer, Rens; Sinisalo, Hanneli; Bakermans-Kranenburg, Marian; IJzendoorn, Marinus H. van

Recent studies have indicated that patterns of infant‐caregiver attachment are associated with differences in infants’ processing of social signals of emotion, such as facial expressions. In the current longitudinal study we extended this line of research to social signals of actual attachment figures by investigating whether 7‐month‐old infants’ neural and attentional responses to their mother's angry and happ...


Family matters: Growing up in family-based care makes a world of a difference

Bakermans-Kranenburg, Marian; Van IJzendoorn, Marinus

Worldwide millions of children and youth live in institutions that may not provide basic conditions for good-enough care, and these numbers are predicted to increase drastically because of the aftermath of the COVID pandemic and wars raging in several parts of the world. We show that three conditions are essential: safe, stable, and shared care (Triple S care). Safe care means a caregiving environment free from...


Video-feedback intervention to promote positive parenting and sensitive discipl...

Starreveld, Kim M.; Overbeek, Mathilde; Willemen, Agnes M.; Bakermans-Kranenburg, Marian

The VIPP-SD (Video-feedback Intervention to promote PositiveParenting and Sensitive Discipline) program has been shown topromote positive interactions between parents and children withbehavior problems. This study evaluated an adapted version forteachers (VIPP-School) through a parallel-group randomized con-trolled trial involving 58 teacher–child dyads from kindergarten tosecond grade. Teacher–child dyads were...


Maternal cognitive functioning and psychopathology predict quality of parent-ch...

PORRECA, ALESSIO; DE CARLI, PIETRO; Filippi, Bianca; Bakermans-Kranenburg, Marian; van IJzendoorn, Marinus; SIMONELLI, ALESSANDRA

This longitudinal study aimed to investigate the role of maternal cognitive functioning and psychopathology in parent-child relationship quality during residential treatment for mothers with Substance Use Disorder (SUD), in order to identify factors that may enhance or limit intervention effects. We assessed cognitive functioning (Esame Neuropsicologico Breve-2 [ENB-2]) and psychopathology (Symptom Checklist-90...


The moderating role of oxytocin in the association between parental support and...

Budniok, Samuel; Bakermans-Kranenburg, Marian; Bosmans, Guy

According to the Learning Theory of Attachment, neuroendocrinological processes affect the association between parental support and change in attachment. The current study aimed to test this assumption for oxytocin (OT) given its role in social behavior. We conducted a three-wave longitudinal study in which 91 children (56% girls, Mage = 9.55, SDage = 0.63) participated. Change in attachment was assessed from W...


The role of psychopathology and emotion regulation in the intergenerational tra...

Nimphy, Cosima; Kullberg, Marie-Louise J.; Pittner, Katharina; Buisman, Renate; van den Berg, Lisa; Alink, Lenneke; Bakermans-Kranenburg, Marian

Previous studies have shown that parents with a history of childhood abuse are at increased risk of perpetrating child abuse. To break the cycle of childhood abuse we need to better understand the mechanisms that play a role. In a cross-sectional extended family design including three generations (N = 250, 59% female), we examined the possible mediating role of parental psychopathology and emotion regulation in...


Celebrating more than 26,000 adult attachment interviews: Mapping the main adul...

Bakermans-Kranenburg, Marian; Dagan, Or; Cárcamo, Rodrigo A.; van IJzendoorn, Marinus

ABSTRACT Since the development of the Adult Attachment Interview (AAI) in 1985, more than 26,000 AAIs have been administered, coded, and reported, representing 170 (wo-)man-years of work. We used multinomial tests and analyses of correspondence to compare the AAI distributions in various cultural and age groups, in mothers, fathers, high-risk, and clinical samples with the combined samples of North American non...


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