5 documents found, page 1 of 1
3D writing of multicellular tendon-on-CNC-chip models
Monteiro, Rosa da Conceição Freitas; Bakht, Syeda Mahwish; Gómez-Florit, M.; Reis, R. L.; Gomes, Manuela E.; Domingues, Rui Miguel AndradeRelevant in vitro models emulating tendinopathies are highly needed to study these diseases and develop better treatments. We have recently proposed a new strategy that allows the automated 3D writing of microphysiological systems (MPS) embedded into its own biomimetic fibrillar support platform based on the self-assembling of cellulose nanocrystals (CNCs). Here, we explored this CNC platform for writing humani...
Writing 3D In vitro models of human tendon within a biomimetic fibrillar suppor...
Monteiro, Rosa F.; Bakht, Syeda Mahwish; Gómez-Florit, Manuel; Stievani, Fernanda C.; Alves, Ana L. G.; Reis, R. L.; Gomes, Manuela E.Tendinopathies are poorly understood diseases for which treatment remains challenging. Relevant in vitro models to study human tendon physiology and pathophysiology are therefore highly needed. Here we propose the automated 3D writing of tendon microphysiological systems (MPSs) embedded in a biomimetic fibrillar support platform based on cellulose nanocrystals (CNCs) self-assembly. Tendon decellularized extra...
Innovative approaches to the use of nanotools for creating tendon tissue-mimeti...
Bakht, Syeda MahwishThe intricate composition and architecture of living tissues determine their functionality, resulting from the complex interplay between cells and the extracellular matrix (ECM). Properly addressing these characteristics is crucial for the development of 3D in vitro advanced platforms that have the potential to enhance the efficacy of knowledge-based therapy development, while significantly reducing the need fo...
Magnetically-assisted 3D bioprinting of anisotropic tissue-mimetic constructs
Pardo, Alberto; Bakht, Syeda Mahwish; Gomez-Florit, Manuel; Rial, Ramón; Monteiro, Rosa Conceiçao Freitas; Teixeira, Simão P. B.; Taboada, PabloRecreating the extracellular matrix organization and cellular patterns of aniso-tropic tissues in bioengineered constructs remains a significant biofabrication challenge. Magnetically-assisted 3D bioprinting strategies can be exploited to fabricate biomimetic scaffolding systems, but they fail to provide control over the distribution of magnetic materials incorporated in the bioinks while pre-serving the fideli...
Natural materials
Gomez-Florit, Manuel; Domingues, Rui Miguel Andrade; Bakht, Syeda Mahwish; Mendes, Bárbara B.; Reis, R. L.; Gomes, Manuela E.The use of naturally occurring materials as scaffolds to support cell growth and proliferation significantly impacted the origin and progress of tissue engineering and regenerative medicine. However, the majority of these materials failed to provide adequate cues to guide cell differentiation toward the formation of new tissues. Over the past decade, a new generation of multifunctional and smart natural-based m...