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Prospective Observational Study on acute Appendicitis Worldwide (POSAW)

Sartelli, M; Baiocchi, GL; Di Saverio, S; Ferrara, F; Labricciosa, FM; Ansaloni, L; Coccolini, F; Vijayan, D; Abbas, A; Abongwa, HK; Agboola, J

BACKGROUND: Acute appendicitis (AA) is the most common surgical disease, and appendectomy is the treatment of choice in the majority of cases. A correct diagnosis is key for decreasing the negative appendectomy rate. The management can become difficult in case of complicated appendicitis. The aim of this study is to describe the worldwide clinical and diagnostic work-up and management of AA in surgical departme...


Intravenous Busulfan for Autologous Stem Cell Transplantation in Adult Patients...

Nagler, A; Labopin, M; Gorin, NC; Ferrara, F; Sanz, M; Wu, D; Gomez, A; Lapusan, S; Irrera, G; Guimaraes, J; Botelho de Sousa, A; Carella, A; Vey, N

Oral busulfan is the historical backbone of the busulfan+cyclophosphamide regimen for autologous stem cell transplantation. However intravenous busulfan has more predictable pharmacokinetics and less toxicity than oral busulfan; we, therefore, retrospectively analyzed data from 952 patients with acute myeloid leukemia who received intravenous busulfan for autologous stem cell transplantation. Most patients were...


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