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Turning a vulnerability into a strength
Balau, Ana; Sobral, Daniel; Medeiros, Márcia; Antunes, Sandra; de Carvalho, Maria Duarte; Morais, Inês; Carvalho, Filomena; Gomes, João PauloMalaria remains a global health challenge and despite the considerable progress made in the mortality rate, the 2025 target of the Global Technical Strategy 2016–2030 is still far from being reached. New strategies to improve patient management, prevent severe cases, and reduce deaths, are urgently needed. Exploring interactions between the malaria parasite and host red blood cells (RBCs) offers opportunities t...
2,3-Diphosphoglycerate and the Protective Effect of Pyruvate Kinase Deficiency ...
Carvalho, Maria; Medeiros, Márcia M.; Morais, Inês; Lopes, Catarina; Balau, Ana; Santos, Nuno C.; Carvalho, Filomena A.; Arez, Ana PaulaMalaria remains a major world public health problem, contributing to poverty and inequality. It is urgent to find new efficacious tools with few adverse effects. Malaria has selected red blood cell (RBC) alterations linked to resistance against infection, and understanding the protective mechanisms involved may be useful for developing host-directed tools to control Plasmodium infection. Pyruvate kinase deficie...
Differential Gene Expression of Malaria Parasite in Response to Red Blood Cell-...
Balau, Ana; Sobral, Daniel; Abrantes, Patrícia; Santos, Inês; Mixão, Verónica; Gomes, João Paulo; Antunes, Sandra; Arez, Ana PaulaInnovative strategies to control malaria are urgently needed. Exploring the interplay between Plasmodium sp. parasites and host red blood cells (RBCs) offers opportunities for novel antimalarial interventions. Pyruvate kinase deficiency (PKD), characterized by heightened 2,3-diphosphoglycerate (2,3-DPG) concentration, has been associated with protection against malaria. Elevated levels of 2,3-DPG, a specific ma...
Synthetic Red Blood Cell-Specific Glycolytic Intermediate 2,3-Diphosphoglycerat...
Morais, Inês; Medeiros, Márcia M.; de Carvalho, Maria; Morello Bullon, Judit; M. Teixeira, Sara; Maciel, Suelma; Nhantumbo, Janice; Balau, AnaMechanisms of malaria parasite interaction with its host red blood cell may provide potential targets for new antimalarial approaches. Pyruvate kinase deficiency has been associated with resistance to malaria in both experimental models and population studies. Two of the major pyruvate kinase deficient-cell disorders are the decrease in ATP and the increase in 2,3-biphosphoglycerate (2,3-BPG) concentration. Hig...