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The expression of the soluble HFE corresponding transcript is up-regulated by i...
Silva, Bruno; Ferreira, Joana; Santos, Vera; Baldaia, Cilénia; Serejo, Fátima; Faustino, PaulaBackground and aims: Dietary iron absorption regulation is a key-step for the maintenance of body iron homeostasis. Besides the HFE full-length protein, the HFE gene codes for alternative splicing variants responsible for the synthesis of a soluble form of HFE protein (sHFE). Here we aimed to determine whether sHFE transcript levels respond to different iron conditions in duodenal, macrophage and hepatic cell m...
The soluble form of HFE protein regulates hephaestin mRNA expression in the duo...
Silva, Bruno; Ferreira, Joana; Santos, Vera; Baldaia, Cilénia; Serejo, Fátima; Faustino, PaulaDietary iron absorption regulation is one of the key steps for the maintenance of the body iron homeostasis. HFE gene expression undergoes a complex post-transcriptional alternative splicing mechanism through which two alternative transcripts are originated and translated to a soluble HFE protein isoform (sHFE). The first purpose of this study was to determine if sHFE transcript levels respond to different iron...
The soluble HFE isoform – a regulator of iron absorption in the duodenum
Silva, Bruno; Ferreira, Joana; Santos, Vera; Sousa, Patícia; Baldaia, Cilénia; Serejo, Fátima; Faustino, PaulaObjective: Dietary iron absorption regulation is a key-step for body iron homeostasis. Once inside the enterocyte, iron is directed to the basolateral membrane being oxidized by hephaestin, which mediates iron efflux towards circulatory transferrin in cooperation with ferroportin. Besides the HFE full-length protein, the HFE gene codes for alternative splicing transcripts responsible for the synthesis of a solu...
The physiological role of the soluble HFE isoform – a regulator of dietary iron...
Silva, Bruno; Ferreira, Joana; Santos, Vera; Sousa, Patrícia; Baldaia, Cilénia; Serejo, Fátima; Faustino, PaulaObjective: Dietary iron absorption regulation is a key-step for body iron homeostasis. Once inside the enterocyte, iron is directed to the basolateral membrane being oxidized by hephaestin, which mediates iron efflux towards circulatory transferrin in cooperation with ferroportin. Besides the HFE full-length protein, the HFE gene codes for alternative splicing transcripts responsible for the synthesis of a solu...
Clinical impact of HFE Mutations in portuguese patients with Chronic Hepatitis C
Ferreira, Joana; Baldaia, Cilénia; Inácio, Ângela; Bicho, Manuel; Velosa, José; Faustino, Paula; Serejo, FátimaINTRODUCTION: Chronic hepatitis C (CHC) is often associated with alterations in iron and lipid metabolisms, which may affect the long-term prognosis and the response to antiviral treatment. Some studies suggested that the occurrence of HFE mutations may contribute to modulate these metabolisms in CHC. Here, the prevalence of two HFE mutations (C282Y and H63D) was determined in a group of Portuguese CHC patients...