8 documents found, page 1 of 1
Modified drug delivery systems for veterinary use: pharmaceutical development a...
Souto, Eliana B.; Barbosa, Catarina I.; Baldim, Iara; Campos, Joana R.; Fernandes, Ana R.; Mazzola, Priscila G.; Andreani, Tatiana; Dias, Isabel R.Scientific research in the field of veterinary pharmacology has provided new opportunities for the development of modified release dosage forms, with the aim to improve therapeutic efficacy and reduce animal stress. The formulation of classical drug molecules with advanced biomaterials has become a new approach to increasing drug bioavailability and improving the therapeutic outcome. The main reasons for the de...
Biofate and cellular interactions of lipid nanoparticles
Baldim, Iara; Oliveira, Wanderley P.; Rao, Rekha; Raghuvir, Singh; Mahant, Sheefali; Gama, F. M.; Souto, Eliana B.By definition, drug targeting and delivery is the process of delivering a drug molecule to a specific site where the pharmacological effect is desired. A targeted release may simplify the drug administration protocols and reduce the amount of drug necessary, thus improving the cost-effectiveness and reducing the side effects. A drug administered by intravenous injection distributes in the whole body, reaching o...
Cyclodextrins-in-liposomes: a promising delivery system for Lippia sidoides and...
Baldim, Iara; Oliveira, Andressa M.; Souto, Eliana Maria Barbosa; Oliveira, Wanderley P.Biological activity of essential oils (EOs) has been extensively reported; however, their low aqueous solubility, high photosensitivity, and volatility compromise a broad industrial use of these compounds. To overcome these limitations, we proposed a nanoencapsulation approach to protect EOs, that aims to increase their stability and modulate their release profile. In this study, drug-in-cyclodextrin-in-liposom...
Natural ergot alkaloids in ocular pharmacotherapy: known molecules for novel na...
Baldim, Iara; Oliveira, Wanderley P.; Kadian, Varsha; Rao, Rekha; Yadav, Nitesh; Mahant, Sheefali; Lucarini, Massimo; Durazzo, AlessandraSeveral pharmacological properties are attributed to ergot alkaloids as a result of their antibacterial, antiproliferative, and antioxidant effects. Although known for their biomedical applications (e.g., for the treatment of glaucoma), most ergot alkaloids exhibit high toxicological risk and may even be lethal to humans and animals. Their pharmacological profile results from the structural similarity between l...
Factors affecting the retention efficiency and physicochemical properties of sp...
Baldim, Iara; Rosa, Débora M.; Souza, Claudia R. F.; Ana, Raquel da; Durazzo, Alessandra; Lucarini, Massimo; Santini, Antonello; Souto, Eliana B.Essential oils (EOs) are widely used in various industrial sectors but can present several instability problems when exposed to environmental factors. Encapsulation technologies are effective solutions to improve EOs properties and stability. Currently, the encapsulation in lipid nanoparticles has received significant attention, due to the several recognized advantages over conventional systems. The study aimed...
Spouted bed dried Rosmarinus officinalis extract: a novel approach for physicoc...
Souza, Claudia R. F.; Baldim, Iara; Bankole, Victor O.; da Ana, Raquel; Durazzo, Alessandra; Lucarini, Massimo; Cicero, Nicola; Santini, AntonelloIn this study, a conical-cylindrical spouted bed dryer with Teflon® beads as spouting material was used for producing powdered rosemary (Rosmarinus officinalis L.) extract. The influence of the inlet drying gas temperature (Tgi) and the percentage ratio between the feed rate of concentrated liquid extract by the maximum evaporation capacity of the spouted bed (Ws/Wmax) on selected physicochemical properties of ...
Spray-dried structured lipid carriers for the loading of Rosmarinus officinalis...
Baldim, Iara; Souza, Claudia R. F.; Durazzo, Alessandra; Lucarini, Massimo; Santini, Antonello; Souto, Eliana B.; Oliveira, Wanderley P.Rosemary, an aromatic herb with significant antioxidative activity, is frequently used as food preservative and a source of nutraceuticals. Its antioxidant effect is mainly related to the presence of phenolic compounds, molecules considerably unstable and prone to irreversible physicochemical changes when exposed to external agents. We here proposed the loading of rosemary into structured lipid systems to impro...
SLN and NLC for topical, dermal, and transdermal drug delivery
Souto, Eliana B.; Baldim, Iara; Oliveira, Wanderley P.; Rao, Rekha; Yadav, Nitesh; Gama, F. M.; Mahant, SheefaliIntroduction: From a biopharmaceutical standpoint, the skin is recognized as an interesting route for drug delivery. In general, small molecules are able to penetrate the stratum corneum, the outermost layer of the skin. In contrast, the delivery of larger molecules, such as peptides and proteins, remains a challenge. Nanoparticles have been exploited not only to enhance skin penetration of drugs but also to ex...