4 documents found, page 1 of 1
Toxoplasma gondii IgG Serointensity Is Positively Associated With Frailty
Mohyuddin, H; Laffon, B; Teixeira, JP; Costa, S; Teixeira-Gomes, A; Pásaro, E; Constantine, N; Dagdag, A; Ortmeyer, HK; Tizenberg, B; Afram, L; Yen, PYBackground: Persistent inflammation related to aging (inflammaging) is exacerbated by chronic infections and contributes to frailty in older adults. We hypothesized associations between Toxoplasma gondii (T. gondii), a common parasite causing an oligosymptomatic unremitting infection, and frailty, and secondarily between T. gondii and previously reported markers of immune activation in frailty.Methods: We analy...
Exploring Early Detection of Frailty Syndrome in Older Adults: Evaluation of Ox...
Teixeira-Gomes, A; Laffon, B; Valdiglesias, V; Gostner, JM; Felder, T; Costa, C; Madureira, J; Fuchs, D; Teixeira, JP; Costa, SAgeing is accompanied with a decline in several physiological systems. Frailty is an age-related syndrome correlated to the loss of homeostasis and increased vulnerability to stressors, which is associated with increase in the risk of disability, comorbidity, hospitalisation, and death in older adults. The aim of this study was to understand the relationship between frailty syndrome, immune activation, and oxid...
Immunological alterations in frail older adults: A cross sectional study
Valdiglesias, V; Marcos-Perez, D; Lorenzi, M; Onder, G; Gostner, JM; Strasser, B; Fuchs, D; Bonassi, SFrailty is a progressive physiologic decline in multiple body systems, characterized by loss of function, loss of physiologic reserve, and increased vulnerability to disease and death. This condition is induced by a complex and multifactorial interaction between genetic, biological, physical, psychological and environmental factors. To understand the interplay between the age-related decline of the immune respo...
Frailty in Older Adults Is Associated With Plasma Concentrations of Inflammator...
Marcos-Perez, D; Sanchez-Flores, M; Maseda, A; Lorenzo-Lopez, L; Millan-Calenti, JC; Gostner, JM; Fuchs, D; Pasaro, E; Laffon, B; Valdiglesias, VFrailty denotes a multidimensional syndrome that gives rise to vulnerability to stressors and leads to an increase of the age-related decline of different physiological systems and cognitive abilities. Aging-related alterations of the immune system may compromise its competence culminating in a chronic low-grade inflammation state. Thus, it has been proposed that frailty is associated with alterations in the co...