161 documents found, page 1 of 17
Metabolism-Targeted Therapy in NSCLC - A New Theranostics Inhalation Approach U...
Mendes, Cindy; Martins, Filipa; Granja, Sara; Gonçalves, Joana; Barros, Hélio; Casimiro, Teresa; Aguiar-Ricardo, Ana; Silva, Fernanda; Abreu, BrunaLung cancer is one of the most lethal cancers globally, primarily due to delayed diagnosis and lack of specific and effective therapy. Increased lactate production and consumption, along with cysteine metabolic reliance, are features identified in NSCLC in our recent studies. Cancer metabolic remodeling leads to excessive ROS production, triggering oxidative stress, promoting angiogenesis, causing cellular and ...
Glucose metabolism as a potential therapeutic target in Cytarabine-resistant ac...
Pereira-Vieira, Joana; Weber, Daniela D.; Silva, Sâmia; Barbosa-Matos, Catarina; Granja, Sara; Reis, Rui Manuel; Queirós, Odília; Ko, Young H.Altered glycolytic metabolism has been associated with chemoresistance in acute myeloid leukemia (AML). However, there are still aspects that need clarification, as well as how to explore these metabolic alterations in therapy. In the present study, we aimed to elucidate the role of glucose metabolism in the acquired resistance of AML cells to cytarabine (Ara-C) and to explore it as a therapeutic target. Resist...
In vitro and in vivo evaluation of novel chromeno[2,3-d]pyrimidinones as therap...
Carvalho, Luísa; Lima, Fábio Pedroso de; Cerqueira, Mónica; Silva, Ana; Pontes, Olívia; Oliveira-Pinto, Sofia; Guerreiro, Sara; Costa, Marta D.Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, and the limited therapeutic options show poor efficacy in patients, associated to severe side effects and development of resistance. Considering that chromene-based scaffolds proved to be attractive candidates for cancer therapy, herein we prepared new chromeno[2,3-d]pyrimidinone derivatives by a simple two step procedure, sta...
Preliminary evaluation of zeolite-based platforms as potential dual drug delive...
Bertão, Ana Raquel; Ivasiv, Viktoriya; Almeida Aguiar, Cristina; Correia, Patrícia R.; Fonseca, António M.; Bañobre-López, Manuel; Baltazar, FátimaSeveral zeolite-based delivery systems (ZDS) built with faujasite structure were prepared containing silver (Ag+) and 5-Fluorouracil (5-FU) as antimicrobial and antineoplastic agents, respectively. The idea behind this drug combination is an answer to the increasing evidence of colonization of tumor microenvironments by pathogenic microorganisms and their active role in tumor growth. Two ZDS with a fixed load o...
The chick chorioallantoic membrane assay as an in vivo model for colon tumor an...
Pereira, Hugo Martins; Freitas, Ruben Brandão; Maciel, Marino Jesus Correia; Pimenta, Sara Filomena Ribeiro; Costa, Marta Sílvia FreitasOptical coherence tomography (OCT) has emerged as a promising imaging modality for biomedical research. In this paper, a commercial OCT system was used to differentiate two colon cell lines implanted in a chick embryo chorioallantoic membrane (CAM) model, using the attenuation coefficient of light. Malignant and non-malignant tumors were developed from RKO and NCM460 cell lines, respectively. OCT B-scan images ...
Machine learning-assisted optimization of drug combinations in zeolite-based de...
Bertão, Ana Raquel; Teixeira, Filipe; Ivasiv, Viktoriya; Parpot, Pier; Almeida Aguiar, Cristina; Fonseca, A. M.; Bañobre-López, Manuel; Baltazar, FátimaTwo independent artificial neural network (ANN) models were used to determine the optimal drug combination of zeolite-based delivery systems (ZDS) for cancer therapy. The systems were based on the NaY zeolite using silver (Ag+) and 5-fluorouracil (5-FU) as antimicrobial and antineoplastic agents. Different ZDS samples were prepared, and their characterization indicates the successful incorporation of both pharm...
Raman spectroscopy for classification of neoplastic and non-neoplastic CAM colo...
Esteves, Bruno Miguel Carpinteiro; Pimenta, Sara Filomena Ribeiro; Maciel, Marino Jesus Correia; Costa, Marta Sílvia Freitas; Baltazar, FátimaThis paper demonstrates the potential of Raman spectroscopy for differentiating neoplastic from non-neoplastic colon tumors, obtained with the CAM (chicken chorioallantoic membrane) model. For the CAM model two human cell lines were used to generate two types of tumors, the RKO cell line for neoplastic colon tumors and the NCM460 cell line for non-neoplastic colon tumors. The Raman spectra were acquired with a ...
Cisplatin-resistant urothelial bladder cancer cells undergo metabolic reprogram...
Afonso, Julieta Alexandra Pereira; Matos, Ana Catarina Barbosa; Silvestre, Ricardo Jorge Leal; Pereira-Vieira, Joana; Gonçalves, Samuel MartinsAdvanced urothelial bladder cancer (UBC) patients are tagged by a dismal prognosis and high mortality rates, mostly due to their poor response to standard-of-care platinum-based therapy. Mediators of chemoresistance are not fully elucidated. This work aimed to study the metabolic profile of advanced UBC, in the context of cisplatin resistance. Three isogenic pairs of parental cell lines (T24, HT1376 and KU1919)...
Targeting lysosomes in colorectal cancer: exploring the anticancer activity of ...
Ferreira, João C. C.; Granja, Sara; Almeida, Ana F.; Baltazar, Fátima; Gonçalves, M. Sameiro T.; Preto, Ana; Sousa, Maria JoãoColorectal cancer (CRC) has been ranked as one of the cancer types with a higher incidence and one of the most mortal. There are limited therapies available for CRC, which urges the finding of intracellular targets and the discovery of new drugs for innovative therapeutic approaches. In addition to the limited number of effective anticancer agents approved for use in humans, CRC resistance and secondary effects...
Sustainable fluorescent dye-faujasite zeolite systems as tools for cancer bioim...
Bertão, Ana R.; Güney, Orhan; Costa, Marta; Fontão, Patrícia; Martinho, Olga; Costa, Susana P. G.; Fonseca, A. M.; Soares, Olívia S. G. P.The use of fluorescent nanoparticles for biological and medical applications has attracted great attention due to their several advantages compared to conventional fluorescent dyes. However, there is also a need for sustainable and versatile alternatives, alongside the streamlining of complex synthesis or preparations. In this work, we study the potential of the faujasite zeolite structure to encapsulate dye mo...