4 documents found, page 1 of 1
Primary bile acid shapes peripheral immunity in inflammatory bowel disease-asso...
Santos, André A.; Pires, David; Marques, Vanda; Alesina, Nicole; Herraez, Elisa; Roudnický, Pavel; Rodrigues, Pedro M.; Godinho-Santos, AnaPrimary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease often associated with underlying inflammatory bowel disease (IBD). This study investigates how PSC predisposes individuals to altered inflammatory immune responses compared with IBD alone. A case–control study was conducted with a cohort of 75 patients, including 16 with PSC (14 with concomitant IBD), 39 with IBD alone, and 20 controls....
MicroRNA-27a-3p targets FoxO signalling to induce tumour-like phenotypes in bil...
Duwe, Lea; Munoz-Garrido, Patricia; Lewinska, Monika; Lafuente-Barquero, Juan; Satriano, Letizia; Høgdall, Dan; Taranta, Andrzej; Nielsen, Boye S.Background & Aims: Cholangiocarcinoma (CCA) is a heterogeneous and lethal malignancy, the molecular origins of which remain poorly understood. MicroRNAs (miRs) target diverse signalling pathways, functioning as potent epigenetic regulators of transcriptional output. We aimed to characterise miRNome dysregulation in CCA, including its impact on transcriptome homeostasis and cell behaviour. Methods: Small RNA seq...
Cirrhosis is associated with lower serological responses to COVID-19 vaccines i...
Simão, André; Palma, Carolina; Izquierdo-Sanchez, Laura; Putignano, Antonella; Carvalho-Gomes, Angela; Posch, Andreas; Zanaga, Paola; Girleanu, IrinaBackground & aims: The response of patients with chronic liver disease (CLD) to COVID-19 vaccines remains unclear. Our aim was to assess the humoral immune response and efficacy of two-dose COVID-19 vaccines among patients with CLD of different aetiologies and disease stages. Methods: A total of 357 patients were recruited in clinical centres from six European countries, and 132 healthy volunteers served as con...
Adiponectin, Leptin, and IGF-1 are useful diagnostic and stratification biomark...
Marques, Vanda; Afonso, Marta; Bierig, Nina; Duarte-Ramos, Filipa; Santos-Laso, Álvaro; Jimenez-Agüero, Raul; Eizaguirre, Emma; Bujanda, LuisBackground: Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease where liver biopsy remains the gold standard for diagnosis. Here we aimed to evaluate the role of circulating adiponectin, leptin, and insulin-like growth factor 1 (IGF-1) levels as non-invasive NAFLD biomarkers and assess their correlation with the metabolome. Materials and Methods: Leptin, adiponectin, and IGF-1 seru...