Submitted by Boris Flegr (boris@uerj.br) on 2021-01-05T18:13:07Z No. of bitstreams: 1 Dissertacao Ana Carla.pdf: 1462180 bytes, checksum: e31472e4f13faa54ff3416ee0af4d837 (MD5); Made available in DSpace on 2021-01-05T18:13:07Z (GMT). No. of bitstreams: 1 Dissertacao Ana Carla.pdf: 1462180 bytes, checksum: e31472e4f13faa54ff3416ee0af4d837 (MD5) Previous issue date: 2012-05-11; Coordenação de Aperfeiçoamento de P...
Background: In addition to the risk of developing ventilator-induced lung injury, patients with ARDS are at risk of developing hyperoxic injury due the supra-physiological oxygen supplementation clinically required to reverse hypoxemia. Alterations of endogenous surfactant system participate in the pulmonary dysfunction observed in ARDS. Administration of exogenous surfactant could have protective effects durin...
Twenty-eight Fischer male rats were divided into four groups: control group (CG), exposed to the ambient air, and groups exposed to formaldehyde (FA) at concentrations of 1% (FA1%), 5% (FA5%) and 10% (FA10%). Kidney function was assessed by dosage of uric acid, creatinine and urea. Morphometry was performed on the thickness of the lumen of Bowman's capsule and diameter of the lumen of the renal tubules. We eval...
Lycopene is a carotenoid with knownantioxidant and anti-inflammatory properties.Weaimed to evaluate the in vitro and in vivo effects of lycopene on reducing the redox imbalance and inflammation induced by cigarette smoke (CS). For the in vitro study, J774A.1 (macrophages) cells were incubated in the presence of 0.5, 1.0, 2.0, 4.0, 8.0, 10.0 and 25 μMof lycopene for 3, 6 and 24 h or in the presence of 0.1%, 0.25...
Programa de Pós-Graduação em Ciências Biológicas. Núcleo de Pesquisas em Ciências Biológicas, Pró-Reitoria de Pesquisa de Pós Graduação, Universidade Federal de Ouro Preto.; O uso do paracetamol (APAP), um fármaco com efeitos antipiréticos e analgésicos, é a principal causa de lesão hepática induzida por drogas. O modelo de lesão hepática induzida por APAP é um dos modelos mais populares para testar potenciais ...
Acetaminophen (APAP) is an antipyretic and analgesic drug that, in high doses, leads to severe liver injury and potentially death. Oxidative stress is an important event in APAP overdose. Researchers are looking for natural antioxidants with the potential to mitigate the harmful effects of reactive oxygen species in different models. Lycopene has been widely studied for its antioxidant properties. The aim of th...
Background: Smoking plays an important role in cardiovascular diseases. However, the reasons why some individuals develop those diseases and others do not remain to be explained. Objective: This study aimed at assessing the redox profile of the heart of different mouse strains after exposure to cigarette smoke. Methods: Male mice of the Swiss (n = 10), C3H (n = 10), BALB/c (n = 10) and C57BL/6 (n = 10) strains ...
The formaldehyde (FA) is a crosslinking agent that reacts with cellular macromolecules such as proteins, nucleic acids and molecules with low molecular weight such as amino acids, and it has been linked to inflammatory processes and oxidative stress. This study aimed to analyze the oxidative effects on pulmonary inflammatory response in Fischer rats exposed to different concentrations of FA. Twenty-eight Fische...
A ventilação mecânica é utilizada como alternativa quando pacientes se encontram em quadros de insuficiência respiratória aguda ou crônica. O presente estudo teve como objetivo apresentar um protótipo que contribuirá para o ensino da ventilação mecânica espontânea e artificial nos cursos das áreas de saúde e biotecnológica. Materiais e Métodos: a pesquisa foi realizada no Laboratório de Biomorfologia e Patologi...
O objetivo deste estudo foi levantar a prevalência e o perfil de tabagistas entre discentes do Curso de Enfermagem da Universidade Severino Sombra. Para isto, durante o período de fevereiro a março de 2009 foi aplicado um questionário para uma amostra de 200 alunos devidamente matriculados e com 18 anos completos. Foi utilizada a análise de prevalência, aproximada em 100%. A prevalência de fumantes, ex-fumantes...