3 documents found, page 1 of 1
Estudo in vitro da atividade tripanocida da crotalicidina - catelicidina da glâ...
Bandeira, Izabel Cristina JustinoCathelicidins are antimicrobial peptides produced by humans and animals in response to various pathogenic microbes. Crotalicidin (Ctn), a cathelicidin-related vipericidin from the South American rattlesnake Crotalus durissus terrificus venom gland, and its fragments have demonstrated antimicrobial and antifungal activity, likewise human cathelicidin LL-37. In order to provide templates for the development of mo...
Estudo dos marcadores de inflamação: associação com os haplótipos do cluster da...
Bandeira, Izabel Cristina JustinoThe Sickle Cell Anemia (SCA) is an inherited disease characterized by homozygous severe hemolytic anemia and clinical variables, considered a chronic inflammatory disease. SCA results from a mutation in a nitrogenous base in the sixth codon of the beta globin gene, leading to substitution of adenine for thymine nucleotide (GAG → GTG), which results in the production of the amino acid valine in place of glutamic...
Clinical events and their relation to the tumor necrosis factor-alpha and inter...
Cavalcante, Jânio Emanuel Andrade; Machado, Rosângela Pinheiro Gonçalves; Laurentino, Marília Rocha; Santos, Talyta Ellen de Jesus dosObjective/background: Sickle-cell anemia (SCA) is a genetic blood disease characterized by chronic inflammation and a heterogeneous clinical picture. Serum tumor necrosis factor (TNF-alpha) and interleukin 10 (IL-10) levels are associated with the clinical course of SCA. This study aimed to evaluate the association between the frequency of the polymorphisms TNF- alpha-308 G ? A, IL-10-1082 G ? A, IL-10-819 C ? ...