5 documents found, page 1 of 1
Prognostic Factors Associated with Disability in a Cohort of Neuromyelitis Opti...
Moura, João; Samões, Raquel; Sousa, Ana Paula; Figueiroa, Sónia; Mendonça, Teresa; Abreu, Pedro; Guimarães, Joana; Melo, Claúdia; Sousa, RaquelIntroduction: Neuromyelitis optica spectrum disorders (NMOSD) and MOG-associated disease (MOGAD) are an increasingly recognized group of demyelinating disorders of the central nervous system. Previous studies suggest that prognosis is predicted by older age at onset, number of relapses, the severity of the first attack and autoantibody status. Objective: To study prognostic factors associated with disability pr...
International Consensus on Antinuclear Antibody em Portugal
Sousa, Maria José; Neves, Esmeralda; Figueiras, Otília; Cruz, Ana Paula; Fernandes, Isabel; Mendes, Alexandra; Santos, Maria do Céu; Cunha, RosárioIntroduction: Screening for autoantibodies in HEp-2 cells by indirect immunofluorescence is currently accepted as the gold-standard test for the diagnosis of systemic autoimmune diseases. The main objective of the International Consensus on ANA Patterns is to achieve a consensus on the nomenclature and description of antinuclear antibody morphological patterns. This work aims to build on the International Conse...
International Consensus on Antinuclear Antibody Patterns in Portugal
Sousa, Maria José; Neves, Esmeralda; Figueiras, Otília; Cruz, Ana Paula; Fernandes, Isabel; Mendes, Alexandra; Santos, Maria do Céu; Cunha, RosárioIntroduction: Screening for autoantibodies in HEp-2 cells by indirect immunofluorescence is currently accepted as the gold-standard test for the diagnosis of systemic autoimmune diseases. The main objective of the International Consensus on ANA Patterns is to achieve a consensus on the nomenclature and description of antinuclear antibody morphological patterns. This work aims to build on the International Conse...
Caracterização das infeções em doentes com Síndrome de deleção 22q11.2
Oliveira, Manuel; Teixeira, Carla; Vasconcelos, Júlia; Neves, Esmeralda; Álvares, Sílvia; Guedes, Margarida; Marques, LauraIntrodução: O Síndrome de deleção 22q11.2 (SD22q11.2) tem uma incidência de 1/2000 a 1/7000 nados-vivos. Caracteriza-se por um grau variável de imunodeficiência que predispõe a infeções, nomeadamente sinopulmonares. Material e métodos: Estudo retrospetivo de 12 doentes, todos apresentando a del22q11.2 de novo, incidindo na caracterização imunológica e no tipo e número de infeções documentadas. Resultados: No qu...
Vitamin D supplementation effects on FoxP3 expression in T cells and FoxP3+/IL-...
Marinho, António; Carvalho, Cláudia; Boleixa, Daniela; Bettencourt, Andreia; Leal, Bárbara; Guimarães, Judite; Neves, Esmeralda; Oliveira, José CarlosSystemic lupus erythematosus (SLE) is a systemic autoimmune disease with multi-organ inflammation, linked to loss of immune tolerance to self-antigens and the production of a diversity of autoantibodies, with a negative impact on the patients' quality of life. Regulatory T cells have been reported as deficient in number and function in SLE patients. However, some authors also described an enrichment of this cel...