20 documents found, page 1 of 2
Use of aminoquinolines (Chloroquine and Hydroxychloroquine) in the treatment of...
Lima, Luan Victor Almeida; Santos, Filipe Saboya; Alves, Nataly Abreu; Alves, Sabrina Sales; Melo, Iury Magalhães Dutra deThe COVID-19 pandemic, caused by the SARS-COV-2 virus, is an infectious disease that to date there is no effective treatment to reduce patient mortality. Hydroxychloroquine (HCQ) and Chloroquine (CQ) are aminoquinoline-derived drugs used in the prevention and treatment of malaria. Initially, aminoquinolines were reported as effective in combating SARS-COV-2 due to their anti-inflammatory and antiviral effects, ...
Zika virus infection and microcephaly: a case-control study in Brazil
Rocha, Sabrina Gabriele Maia Oliveira; Correia, Luciano Lima; Cunha, Antônio José Lêdo Alves da; Rocha, Hermano Alexandre LimaBackground: Brazil presented an alarming number of newborns with microcephaly in the years 2015 and 2016. The investigation of the cases raised the suspicion of the association of these cases with maternal infections by the zika virus. Also, in 2015, there was an epidemic of zika virus infection in Brazil, reinforcing this hypothesis. Objective: The objective of this study was to identify factors associated wit...
Aeromonas and Plesiomonas species from scarlet ibis ( Eudocimus ruber ) and the...
Castelo-Branco, Débora Souza Collares Maia; Silva, Aline Lobão da; Monteiro, Frederico Ozanan Barros; Guedes, Glaucia Morgana de MeloThe present study aimed at evaluating the role of captive scarlet ibises (Eudocimus ruber) and their environment as reservoirs of Aeromonas spp. and Plesiomonas spp., and analyzing the in vitro antimicrobial susceptibility and virulence of the recovered bacterial isolates. Thus, non-lactose and weak-lactose fermenting, oxidase positive Gram-negative bacilli were recovered from cloacal samples (n = 30) of scarle...
Enterobacteria and Vibrio from Macrobrachium amazonicum prawn farming in Fortal...
Castelo-Branco, D ebora de Souza Collares Maia; Sales, Jamille Alencar; Brilhante, Raimunda Sâmia Nogueira; Guedes, Glaucia Morgana de MeloObjective: To investigate the isolation of enterobacteria associated with Macrobrachium amazonicum (M. amazonicum) farming and evaluate the in vitro antimicrobial susceptibility of Vibrio strains. Methods: Strains were isolated from female M. amazonicum prawns and environmental and hatchery water. Biochemical assays were used to identify bacterial genera and those belonging to the genus Vibrio were submitted to...
Vibrio spp. from Macrobrachium amazonicum prawn farming are inhibited by Moring...
Brilhante, Raimunda Sâmia Nogueira; Sales, Jamille Alencar; Sampaio, Celia Maria de Souza; Barbosa, Francisco Geraldo; Paiva, Manoel de Araújo NetoObjective To investigate the in vitro antimicrobial potential of extracts of stem, leaves, flowers, pods and seeds of Moringa oleifera (M. oleifera) against Vibrio spp. from hatchery water and the prawn Macrobrachium amazonicum. Methods The ethanol extracts of stem, leaves, pods and seeds and chloroform extract of flowers of M. oleifera were tested against Vibrio cholerae (V. cholerae) serogroups non-O1/non-O13...
In vitro inhibitory activity of terpenic derivatives against clinical and envir...
Brilhante, Raimunda Sâmia Nogueira; Marques, Natalya Fechine Silva; Castelo-Branco, Débora de Souza Collares Maia; Lima, Rita Amanda Chaves deSporotrichosis is a subacute or chronic subcutaneous infection, caused by the fungus Sporothrix schenkii complex, occurring in human and animal tissues. Potassium iodide and itraconazole have been used as effective therapy for first-choice treatment, while am- photericin B may be indicated for disseminated infection. However, the adverse effects of potassium iodide and amphotericin B or the long duration of the...
Evidence of fluconazole-resistant Candida species in tortoises and sea turtles
Brilhante, Raimunda Sâmia Nogueira; Rodrigues, Pedro Henrique de Aragão; Alencar, Lucas Pereira de; Riello, Giovanna Barbosa; Ribeiro, Joyce FontelesThe aim of this study was to evaluate the antifungal susceptibility of Candida spp. recovered from tortoises ( Chelonoidis spp.) and sea turtles ( Chelonia mydas , Caretta caretta , Lepidochelys oli- vacea , Eretmochelys imbricata ). For this purpose, material from the oral cavity and cloaca of 77 animals (60 tortoises and 17 sea turtles) was collected. The collected specimens were seeded on 2 % Sabouraud dextr...
Easy storage strategies for sporothrix spp. strains
Brilhante, Raimunda Sâmia Nogueira; Silva, Natalya Fechine; Lima, Rita Amanda Chaves de; Caetano, Érica Pacheco; Alencar, Lucas Pereira deThe present study evaluated the maintenance of Sporothrix spp. (6 Sporothrix brasiliensis;6S. schenckii;5 S. mexicana, and 3 S. globosa) in saline at 4 C, and in 10% glycerol plus either 10% lactose or 10% sucrose, at -20 C and -80 C. Viability was assessed after 3, 6, and 9 months of storage, through the recovery of strains on potato dextrose agar and analysis of macro- and micromorphological features. Conidiu...
Simvastatin inhibits planktonic cells and biofilms of Candida and Cryptococcus ...
Brilhante, Raimunda Sâmia Nogueira; Caetano, Erica Pacheco; Oliveira, Jonathas Sales de; Castelo-Branco, Débora de Souza Collares MaiaThe antifungal activity of some statins against different fungal species has been reported. Thus, at the first moment, the in vitro antifungal activity of simvastatin, atorvastatin and pravastatin was tested against Candida spp. and Cryptococcus spp. Then, in a second approach, considering that the best results were obtained for simvastatin, this drug was evaluated in combination with antifungal drugs against p...
Synthesis and in vitro antifungal activity of isoniazid-derived hydrazones agai...
Cordeiro, Rossana de Aguiar; Melo, Charlline Vládia Silva de; Marques, Francisca Jakelyne de Farias; Serpa, Rosana; Evangelista, Antônio José de JesusCoccidioidomycosis is a potentially severe infection caused by dimorphic fungi Coccidioides immitis and Coccidioides posadasii . Although guidelines are well established, refractory disease is a matter of concern in the clinical management of coccidioidomycosis. In the present study three isoniazid-derived hydra- zones N 0 -[( E )-1-(4-methoxyphenyl)ethylidene]pyridine-4-carbohydrazide, N 0 -[( E )-1-(4-methylp...