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Molecular characterization of the complement C1q, C2 and C4 genes in Brazilian ...

Liphaus, Bernadete L.; Umetsu, Natalia; Jesus, Adriana A.; Bando, Silvia Y.; Silva, Clovis A.; Carneiro-Sampaio, Magda

OBJECTIVE: To perform a molecular characterization of the C1q, C2 and C4 genes in patients with juvenile systemic lupus erythematosus. METHODS: Patient 1 (P1) had undetectable C1q, patient 2 (P2) and patient 3 (P3) had decreased C2 and patient 4 (P4) had decreased C4 levels. All exons and non-coding regions of the C1q and C2 genes were sequenced. Mononuclear cells were cultured and stimulated with interferon ga...

Date: 2015   |   Origin: Oasisbr
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