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LPS-induced mitochondrial dysfunction regulates innate immunity activation and ...
Esteves, A. Raquel; Silva, Diana F. F.; Banha, Diogo; Candeias, Emanuel; Guedes, Beatriz; Cardoso, Sandra M.Sporadic Parkinson's disease (sPD) is a complex multifactorial disorder which etiology remains elusive. Several mechanisms have been described to contribute to PD development namely mitochondrial dysfunction, activation of inflammatory pathways and the deposition of unfolded proteins such as α-synuclein. Our work shows for the first time that lipopolysaccharide (LPS)-induced activation of innate immunity requir...
Date: 2023
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Origin: Estudo Geral - Universidade de Coimbra