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3-bromopyruvate boosts the effect of chemotherapy in acute myeloid leukemia by ...
Vieira, Joana Margarida Pereira; Celeiro, Sónia Pires; Granja, Sara Costa; Matos, Ana Catarina Barbosa; Preto, Ana; Queirós, Odília; Ko, Young
Date: 2020
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Origin: RepositóriUM - Universidade do Minho
Non-toxic concentrations of 3-bromopyruvate sensitize acute leukemia cells to c...
Vieira, Joana Margarida Pereira; Granja, Sara Costa; Matos, Ana Catarina Barbosa; Ko, Young; Preto, Ana; Queirós, Odília; Casal, Margarida
Date: 2020
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Origin: RepositóriUM - Universidade do Minho
3-Bromopyruvate pre-treatment sensitizes MOLM13 and KG-1 cell lines to chemothe...
Vieira, Joana Margarida Pereira; Granja, Sara Costa; Matos, Ana Catarina Barbosa; Ko, Young; Preto, Ana; Queirós, Odília; Casal, Margarida
Date: 2019
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Origin: RepositóriUM - Universidade do Minho
3-bromopyruvate, butyrate, monocarboxylate transporters, warburg effect
Queirós, Odília; Preto, Ana; Pacheco, António; Pinheiro, Céline; Silva, João Azevedo; Moreira, Roxana; Pedro, Madalena; Ko, Young; Pedersen, PeterMost malignant tumors exhibit theWarburg effect, which consists in increased glycolysis rates with production of lactate, even in the presence of oxygen. Monocarboxylate transporters (MCTs), maintain these glycolytic rates, by mediating the influx and/or efflux of lactate and are overexpressed in several cancer cell types. The lactate and pyruvate analogue 3-bromopyruvate (3-BP) is an inhibitor of the energy me...
Date: 2012
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Origin: RepositóriUM - Universidade do Minho