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Anti-HMGCR Immune-Mediated Myopathy: Literature Review Based in a Case Report

Baptista, Bernardo; Galaz Tavares, João; Marto, Natália; Bayão Horta, Alexandra; Roque, Rafael

Statins are amongst the most prescribed drugs worldwide and they are generally safe. A rare but potentially serious adverse effect of statins’ therapy has been described– anti-3-hydroxy-3-methyl-glutaryl-coenzyme A reductase (anti-HMGCR) immune-mediated necrotizing myopathy (IMNM) – that can occur years after the drug has beenstarted. We conducted a literature review after illustratinga typical case of anti-HMG...


LEVOSIMENDAN IN SINGLE VENTRICLE HEART FAILURE AFTER LONGTERM SURVIVAL OF A MOD...

Tavares, João; Baptista, Bernardo; Sarmento, Pedro; Gonçalves, Bebiana; Abecassis, Miguel

We report the case of a 44 year-old patient with complex ACHD, admitted with acute decompensated heart failure (ADHF) in hemodynamic profile B. He had a single ventricle with pulmonary atresia, previously submitted to three modified Blalock-Taussig shunts (mBTs) at the age of 2, 12 and 19 years old. Despite conventional treatment with diuretics, β-blockers (BB) and isosorbide dinitrate the patient progressed to...


Mechanic's Hands and Drug Eruption to Hydroxychloroquine: Precious Diagnostic T...

Sanches, Maria Mendonça; Pimenta, Rita; Cordeiro, Inês; Baptista, Bernardo

The clinical diagnosis of dermatomyositis can be difficult and challenging. In the right clinical setting and with the use of the recently described myositis specific antibodies, an earlier diagnosis can be made and therapeutic approaches promptly started, minimizing the risk of disease progression. We herein present a case of a patient with mechanic’s hands and a previously documented drug eruption to hydroxyc...


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