14 documents found, page 1 of 2
Neonatal testosterone voids sexually differentiated microglia morphology and be...
Simões-Henriques, Carla Filipa; Rodrigues-Neves, A. Catarina; Sousa, Fábio J.; Gaspar, Rita; Almeida, Inês; Baptista, Filipa I.The involvement of immunity in psychiatric disorders, such as anxiety, is typified by the morphologic adaptation of microglia, immune cells of the brain, to anxiogenic stimuli. We previously reported sexually differentiated microglia morphology in adult rodents, in brain locations implicated in anxiety, including the pre-frontal cortex. These physiologic differences likely drive sex-dependent patterns of microg...
Postnatal Overfeeding in Rodents Induces a Neurodevelopment Delay and Anxious-l...
Amaro, Andreia; Sousa, Diana Isabel Teixeira de; Sá-Rocha, Mariana; Ferreira-Junior, Marcos Divino; Rosendo-Silva, DanielaNutritional disturbances during the early postnatal period can have long-lasting effects on neurodevelopment and may be related to behavioural changes at adulthood. While such neuronal connection disruption can contribute to social and behaviour alterations, the dysregulation of the neuroendocrine pathways involved in nutrient-sensing balance may also cause such impairments, although the underlying mechanisms a...
Microglial Rac1 is essential for experience-dependent brain plasticity and cogn...
Socodato, Renato; Almeida, Tiago O.; Portugal, Camila C.; Santos, Evelyn C.S.; Tedim-Moreira, Joana; Ferreira, João Galvão; Canedo, TeresaMicroglia, the largest population of brain immune cells, continuously interact with synapses to maintain brain homeostasis. In this study, we use conditional cell-specific gene targeting in mice with multi-omics approaches and demonstrate that the RhoGTPase Rac1 is an essential requirement for microglia to sense and interpret the brain microenvironment. This is crucial for microglia-synapse crosstalk that drive...
Resilience to stress and sex-specific remodeling of microglia and neuronal morp...
Gaspar, Rita; Soares-Cunha, Carina; Domingues, Ana Verónica; Coimbra, Bárbara; Baptista, Filipa I.; Pinto, Luísa; Ambrósio, António; Rodrigues, Ana JoãoPrenatal exposure to stress or glucocorticoids (GC) is associated with the appearance of psychiatric diseases later in life. Microglia, the immune cells of the brain, are altered in stress-related disorders. Synthetic GC such as dexamethasone (DEX) are commonly prescribed in case of preterm risk labour in order to promote fetal lung maturation. Recently, we reported long-lasting differences in microglia morphol...
Microglia dysfunction caused by the loss of rhoa disrupts neuronal physiology a...
Socodato, Renato; Portugal, Camila C.; Canedo, Teresa; Rodrigues, Artur; Almeida, Tiago O.; Henriques, Joana F.; Vaz, Sandra H.; Magalhães, JoãoNervous tissue homeostasis requires the regulation of microglia activity. Using conditional gene targeting in mice, we demonstrate that genetic ablation of the small GTPase Rhoa in adult microglia is sufficient to trigger spontaneous microglia activation, producing a neurological phenotype (including synapse and neuron loss, impairment of long-term potentiation [LTP], formation of β-amyloid plaques, and memory ...
Microglia dysfunction caused by the loss of Rhoa disrupts neuronal physiology a...
Socodato, Renato; Portugal, Camila C.; Canedo, Teresa; Rodrigues, Artur; Almeida, Tiago O.; Henriques, Joana F.; Vaz, Sandra H.; Magalhães, JoãoNervous tissue homeostasis requires the regulation of microglia activity. Using conditional gene targeting in mice, we demonstrate that genetic ablation of the small GTPase Rhoa in adult microglia is sufficient to trigger spontaneous microglia activation, producing a neurological phenotype (including synapse and neuron loss, impairment of long-term potentiation [LTP], formation of β-amyloid plaques, and memory ...
Elevated Glucose and Interleukin-1β Differentially Affect Retinal Microglial Ce...
Baptista, Filipa I.; Aveleira, Célia A.; Castilho, Áurea F.; Ambrósio, António F.Diabetic retinopathy is considered a neurovascular disorder, hyperglycemia being considered the main risk factor for this pathology. Diabetic retinopathy also presents features of a low-grade chronic inflammatory disease, including increased levels of cytokines in the retina, such as interleukin-1 beta (IL-1β). However, how high glucose and IL-1β affect the different retinal cell types remains to be clarified. ...
Role of microglia adenosine A(2A) receptors in retinal and brain neurodegenerat...
Santiago, Ana R.; Baptista, Filipa I.; Santos, Paulo; Cristovão, Gonçalo; Ambrósio, A. Francisco; Cunha, Rodrigo A.; Gomes, Catarina A.Neuroinflammation mediated by microglial cells in the brain has been commonly associated with neurodegenerative diseases. Whether this microglia-mediated neuroinflammation is cause or consequence of neurodegeneration is still a matter of controversy. However, it is unequivocal that chronic neuroinflammation plays a role in disease progression and halting that process represents a potential therapeutic strategy....
Diabetes induces changes in KIF1A, KIF5B and dynein distribution in the rat ret...
Baptista, Filipa I.; Pinto, Maria J.; Elvas, Filipe; Martins, Tiago; Almeida, Ramiro D.; Ambrósio, António F.Diabetic retinopathy is a leading cause of vision loss and blindness. Disruption of axonal transport is associated with many neurodegenerative diseases and might also play a role in diabetes-associated disorders affecting nervous system. We investigated the impact of type 1 diabetes (2 and 8 weeks duration) on KIF1A, KIF5B and dynein motor proteins in the retina. Additionally, since hyperglycemia is considered ...
Diabetes alters KIF1A and KIF5B motor proteins in the hippocampus
Baptista, Filipa I.; Pinto, Maria J.; Elvas, Filipe; Almeida, Ramiro D.; Ambrósio, A. FranciscoDiabetes mellitus is the most common metabolic disorder in humans. Diabetic encephalopathy is characterized by cognitive and memory impairments, which have been associated with changes in the hippocampus, but the mechanisms underlying those impairments triggered by diabetes, are far from being elucidated. The disruption of axonal transport is associated with several neurodegenerative diseases and might also pla...