6 documents found, page 1 of 1
Impact of antibiotic therapy in severe community-acquired pneumonia: Data from ...
Pereira, JM; Gonçalves-Pereira, J; Ribeiro, O; Baptista, JP; Froes, F; Paiva, JAAntibiotic therapy (AT) is the cornerstone of the management of severe community-acquired pneumonia (CAP). However, the best treatment strategy is far from being established. To evaluate the impact of different aspects of AT on the outcome of critically ill patients with CAP, we performed a post hoc analysis of all CAP patients enrolled in a prospective, observational, multicentre study. Of the 502 patients inc...
Decreasing the time to achieve therapeutic vancomycin concentrations in critica...
Baptista, JP; Roberts, JA; Sousa, E; Freitas, R; Deveza, N; Pimentel, JINTRODUCTION: Achievement of optimal vancomycin exposure is crucial to improve the management of patients with life-threatening infections caused by susceptible Gram-positive bacteria and is of particular concern in patients with augmented renal clearance (ARC). The aim of this study was to develop a dosing nomogram for the administration of vancomycin by continuous infusion for the first 24 hours of therapy ba...
Augmented renal clearance in septic patients and implications for vancomycin op...
Baptista, JP; Sousa, E; Martins, PJ; Pimentel, JMThe aim of this study was to evaluate the effect of augmented renal clearance (ARC) on vancomycin serum concentrations in critically ill patients. This prospective, single-centre, observational, cohort study included 93 consecutive, critically ill septic patients who started treatment that included vancomycin by continuous infusion, admitted over a 2-year period (March 2006 to February 2008). ARC was defined as...
A comparison of estimates of glomerular filtration in critically ill patients w...
Baptista, JP; Udy, AA; Sousa, E; Pimentel, J; Wang, L; Roberts, JA; Lipman, JINTRODUCTION: Increasingly, derived estimates of glomerular filtration, such as the modification of diet in renal disease (MDRD) equation and Cockcroft-Gault (CG) formula are being employed in the intensive care unit (ICU). To date, these estimates have not been rigorously validated in those with augmented clearances, resulting in potentially inaccurate drug prescription. METHODS: Post-hoc analysis of prospecti...
Hérnias diafragmáticas traumáticas: revisão casuística
Almeida e Sousa, JP; Baptista, JP; Martins, L; Pimentel, JAIMS: This study classifies cases of traumatic diaphragmatic hernias (TDH) in patients admitted to the Intensive Care Unit (ICU) of the Coimbra University Hospitals (HUC) from 1990 to 2004. METHODS: Retrospective analysis of 34 cases of TDH, studying anatomical location, place and time of diagnosis, complementary tests aiding diagnosis, herniated organs, associated traumatism, morbidity and mortality. RESULTS: ...
Pneumonia eosinofílica aguda com evolução para síndroma de dificuldade respirat...
Baptista, JP; Casanova, PC; Almeida e Sousa, JP; Martins, JP; Simões, A; Fernandes, V; Souto, J; Costa, JJ; Carvalho, L; Pimentel, JThe Authors present a case of acute eosinophilic pneumonia (AEP) associated with severe acute respiratory distress syndrome in a previously healthy young adult, medicated with nitrofurantoin. AEP must be included in the differential diagnosis of community adquired pneumonia, as well as a cause of acute respiratory distress syndrome; its diagnosis is suggested by the presence of eosinophilic alveolitis in bronch...