8 documents found, page 1 of 1
Dense motion field estimation from myocardial boundary displacements
Morais, Pedro; Queirós, Sandro; Ferreira, Adriano; Rodrigues, Nuno F.; Baptista, Maria J.; D’hooge, Jan; Vilaça, João L.; Barbosa, DanielMinimally invasive cardiovascular interventions guided by multiple imaging modalities are rapidly gaining clinical acceptance for the treatment of several cardiovascular diseases. These images are typically fused with richly detailed pre-operative scans through registration techniques, enhancing the intra-operative clinical data and easing the image-guided procedures. Nonetheless, rigid models have been used to...
Robust temporal alignment of multimodal cardiac sequences
Perissinotto, Andrea; Queirós, Sandro; Morais, Pedro; Baptista, Maria J.; Monaghan, Mark; Rodrigues, Nuno F.; Vilaça, João L.; Barbosa, DanielGiven the dynamic nature of cardiac function, correct temporal alignment of pre-operative models and intraoperative images is crucial for augmented reality in cardiac image-guided interventions. As such, the current study focuses on the development of an image-based strategy for temporal alignment of multimodal cardiac imaging sequences, such as cine Magnetic Resonance Imaging (MRI) or 3D Ultrasound (US). First...
Improving The Robustness Of Interventional 4D Ultrasound Segmentation Through T...
Barbosa, Daniel; Queirós, Sandro; Morais, Pedro; Baptista, Maria J.; Monaghan, Mark; Rodrigues, Nuno F.; D’hooge, Jan; Vilaça, João L.While fluoroscopy is still the most widely used imaging modality to guide cardiac interventions, the fusion of pre-operative Magnetic Resonance Imaging (MRI) with real-time intra-operative ultrasound (US) is rapidly gaining clinical acceptance as a viable, radiation-free alternative. In order to improve the detection of the left ventricular (LV) surface in 4D ultrasound, we propose to take advantage of the pre-...
Dense motion field estimation from myocardial boundary displacements
Morais, Pedro; Queirós, Sandro Filipe Monteiro; Ferreira, Adriano; Rodrigues, Nuno F.; Baptista, Maria J.; D'hooge, Jan; Vilaça, João L.Minimally invasive cardiovascular interventions guided by multiple imaging modalities are rapidly gaining clinical acceptance for the treatment of several cardiovascular diseases. These images are typically fused with richly detailed pre-operative scans through registration techniques, enhancing the intra-operative clinical data and easing the image-guided procedures. Nonetheless, rigid models have been used to...
Pulmonary epithelial cell differentiation in the nitrofen-induced congenital di...
Santos, Marta; Silva, Cristina Isabel Nogueira; Baptista, Maria J.; Soares-Fernandes, João; Moura, Rute S.; Correia-Pinto, JorgeBackground/Aim: In congenital diaphragmatic hernia (CDH), there is pulmonary neuroendocrine cell (PNEC) hyperplasia and Clara (nonendocrine) cell hypoplasia, the meaning of which remains unknown. In embryonic/fetal lung, an intricate cross talk between Notch pathway and basic helix-loop-helix transcription factors Mash 1 and Hes 1 determines the balance between endocrine and nonendocrine epithelial cell fate. D...
IL-6 is constitutively expressed during lung morphogenesis and enhances fetal l...
Silva, Cristina Isabel Nogueira; Santos, Marta; Baptista, Maria J.; Moura, Rute S.; Correia-Pinto, JorgePrevious studies have shown that chorioamnionitis, with increased IL-6, promotes fetal lung maturation and decreases the incidence of respiratory distress syndrome in premature neonates. However, the expression pattern and the effects of IL-6 on fetal lung growth mechanisms remain unknown. IL-6 expression was assessed by in situ hybridization and by real-time PCR between 14.5 and 21.5 d postconception. Normal a...
Ghrelin expression in human and rat fetal lungs and the effect of ghrelin admin...
Santos, Marta; Bastos, Pedro; Gonzaga, Silvia; Roriz, José-Mário; Baptista, Maria J.; Silva, Cristina Isabel Nogueira; Rocha, Gustavo Filipe Melo AlvesGhrelin is a strong physiologic growth hormone secretagogue that exhibits endocrine and non-endocrine actions. In this study, ghrelin expression in humans and rats was evaluated throughout development of normal and hypoplastic lungs associated with congenital diaphragmatic hernia (CDH). Additionally, the effect of antenatal treatment with ghrelin in the nitrofen-induced CDH rat model was tested. In normal lungs...
Antenatal vitamin A administration attenuates lung hypoplasia by interfering wi...
Baptista, Maria J.; Rocha, Gustavo Filipe Melo Alves; Pedrosa, Carla; Gonzaga, Sílvia; Teles, Antónia; Estevão-Costa, José; Areias, José C.Early and late lung underdevelopment in congenital diaphragmatic hernia (CDH) is likely caused by nonmechanical (directly mediated by nitrofen) and mechanical (mediated by thoracic herniation) factors, respectively. The authors investigated if vitamin A enhances lung growth because of effects on both early and late determinants of lung hypoplasia. Background/Purpose Early and late lung underdevelopment in conge...