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Bringing hope to improve treatment in pancreatic ductal adenocarcinoma - a new ...
Bravo, Ana Catarina; Morão, Bárbara; Luz, André; Dourado, Rúben; Oliveira, Beatriz; Guedes, Ana; Moreira-Barbosa, Catarina; Fidalgo, CatarinaBackground/Objectives: Pancreatic ductal adenocarcinoma (PDAC) incidence is rising, and prognosis remains poor due to late diagnosis and limited effective therapies. Currently, patients are treated based on TNM staging, without molecular tumor characterization. This study aimed to validate a technique that combines the amplification refractory mutation system (ARMS) with high-resolution melting analysis (HRMA) ...
Combining the amplification refractory mutation system and high-resolution melt...
Oliveira, Beatriz B.; Costa, Beatriz; Morão, Barbara; Faias, Sandra; Veigas, Bruno; Pereira, Lucília Pebre; Albuquerque, Cristina; Maio, RuiThe success of personalized medicine depends on the discovery of biomarkers that allow oncologists to identify patients that will benefit from a particular targeted drug. Molecular tests are mostly performed using tumor samples, which may not be representative of the tumor's temporal and spatial heterogeneity. Liquid biopsies, and particularly the analysis of circulating tumor DNA, are emerging as an interestin...
Experimental optimization of a passive planar rhombic micromixer with obstacles...
Bernacka-Wojcik, I.; Ribeiro, S.; Jerzy Wojcik, P.; Alves, P. Urbano; Busani, T.; Fortunato, Elvira; Baptista, Pedro Viana; Covas, J. A.; Aguas, HThis paper presents the performance of a passive planar rhombic micromixer with diamond-shaped obstacles and a rectangular contraction between the rhombi. The device was experimentally optimized using water for high mixing efficiency and a low pressure drop over a wide range of Reynolds numbers (Re ¼ 0.1–117.6) by varying geometrical parameters such as the number of rhombi, the distance between obstacles and th...
Association of FTO and PPARG polymorphisms with obesity in Portuguese women
Carlos, Fábio Ferreira; Silva-Nunes, José; Flores, Orfeu; Brito, Miguel; Doria, Gonçalo; Veiga, Luísa; Baptista, Pedro VianaPurpose: We evaluated the association between risk of obesity in the Portuguese population and two obesity-related single-nucleotide gene polymorphisms: fat-mass and obesity-associated (FTO) rs9939609 and peroxisome proliferator-activated receptor gamma (PPARG) rs1801282. Patients and methods: A total of 194 Portuguese premenopausal female Caucasians aged between 18 and 50 years (95 with body mass index [BMI] ≥...