2 documents found, page 1 of 1
Shape-versatile fixed cellular materials for multiple target immunomodulation
Sousa, Ana Rita; Cunha, Ana F.; Santos-Coquillat, Ana; Estrada, Beatriz Hernaez; Spiller, Kara L.; Barão, Marta; Rodrigues, Artur Filipe; Simões, SusanaTherapeutic cells are usually administered as living agents, despite the risks of undesired cell migration and acquisition of unpredictable phenotypes. Additionally, most cell-based therapies rely on the administration of single cells, often associated with rapid in vivo clearance. Three-dimensional cellular materials may be useful to prolong the effect of cellular therapies and offer the possibility of creatin...
Extracellular vesicles enriched with an endothelial cell pro-survival microRNA ...
Fernandes, Hugo; Zonnari, Alessandra; Abreu, Ricardo Cerqueira de; Aday, Sezin; Barão, Marta; Albino, Inês; Lino, Miguel; Branco, Ana; Seabra, CátiaEndothelial cell (EC) activity is essential for tissue regeneration in several (patho)physiological contexts. However, our capacity to deliver in vivo biomolecules capable of controlling EC fate is relatively limited. Here, we screened a library of microRNA (miR) mimics and identified 25 miRs capable of enhancing the survival of ECs exposed to ischemia-mimicking conditions. In vitro, we showed that miR-425-5p, ...