8 documents found, page 1 of 1
Size-Exclusion Chromatography
Grenhas, Madalena; Lopes, Raquel; Ferreira, Bruna Velosa; Barahona, Filipa; João, Cristina; Carneiro, Emilie ArnaultFunding Information: The authors express their gratitude to the Electron Microscopy Unit of Instituto Gulbenkian de Ci\u00EAncia (IGC) for the acquisition of the EV images. Additionally, we extend our appreciation to Carolina Pestana MSc for her contribution to the statistical analysis of this study, to the Systems Oncology Research Group (Champalimaud Foundation) for granting access to the required equipment f...
Correction to
Ferreira, Bruna; Caetano, Joana; Barahona, Filipa; Lopes, Raquel; Carneiro, Emilie; Costa-Silva, Bruno; João, CristinaFunding Information: Funding This research was funded by the Funda\u00E7\u00E3o para a Ci\u00EAncia e Tecnologia \u2013 FCT (Research Grant PTDC/MEC-HEM/30315/2017). Publisher Copyright: © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024.; We mistakenly forgot to mention the funding for this paper. Funding This research was funded by the Fundação para a Ciênci...
Is Circulating DNA and Tumor Cells in Myeloma the Way Forward?
Arnault Carneiro, Emilie; Barahona, Filipa; Pestana, Carolina; João, CristinaFunding Information: This research was funded by the Champalimaud Foundation; by the Fundação para a Ciência e Tecnologia—FCT (Research Grant PTDC/MEC-HEM/30315/2017). Publisher Copyright: © 2022 by the authors.; Multiple myeloma (MM) is the second deadliest hematological cancer. Despite the enormous innovation on MM treatment in the last decades, still 48% of patients die within 5 years after diagnosis. MM dia...
Patient-Derived Extracellular Vesicles Proteins as New Biomarkers in Multiple M...
Ferreira, Bruna Velosa; Carneiro, Emilie Arnault; Pestana, Carolina; Barahona, Filipa; Caetano, Joana; Lopes, Raquel; Lúcio, Paulo; Neves, ManuelFunding Information: This research was funded by the Champalimaud Foundation; by the Fundação para a Ciência e Tecnologia – FCT (Research Grant PTDC/MEC-HEM/30315/2017) and by Sociedade Portuguesa de Hematologia -SPH (Initiation to Investigation Grant 2018).; Multiple myeloma (MM) is a hematological malignancy of clonal antibody–secreting plasma cells (PCs). MM diagnosis and risk stratification rely on bone mar...
Multiple Myeloma-Derived Extracellular Vesicles Modulate the Bone Marrow Immune...
Lopes, Raquel; Caetano, Joana; Barahona, Filipa; Pestana, Carolina; Ferreira, Bruna Velosa; Lourenço, Diana; Queirós, Ana C.; Bilreiro, CarlosFunding Information: This work was supported by Portuguese national funds, through FCT—Fundação para a Ciência e Tecnologia—in the context of the projects PDTC/MEC-HEM/30315/2017 and PCDC/MED-ONC/1215/2021, and by GILEAD GÉNESE (project PGG/058/2019). RL received a fellowship funded by FCT (2020.4875.BD). This work was also supported by the research infrastructure CONGENTO, co-financed by Lisboa Regional Operat...
Measurable Residual Disease Assessment in Multiple Myeloma
Caetano, Joana; Barahona, Filipa; Lúcio, Paulo; João, CristinaPublisher Copyright: © 2022 by the authors.; The introduction of new and more effective therapeutic options for Multiple Myeloma (MM) has significantly deepened and prolonged patients’ remission. As currently used treatment protocols induce high rates of complete responses, Measurable Residual Disease (MRD) assessment has become essential to enhance the evaluation of treatment efficacy. Detection of MRD has imp...
The immune microenvironment in multiple myeloma
Lopes, Raquel; Caetano, Joana; Ferreira, Bruna; Barahona, Filipa; Carneiro, Emilie Arnault; João, CristinaFunding: This research was funded by Fundação para a Ciência e Tecnologia (FCT), PTDC/MECHEM/30315/2017.; Multiple myeloma (MM) is one of the most prevalent hematological cancers worldwide, characterized by the clonal expansion of neoplastic plasma cells in the bone marrow (BM). A combination of factors is implicated in disease progression, including BM immune microenvironment changes. Increasing evidence sugge...
Boosting immunity against multiple myeloma
Lopes, Raquel; Ferreira, Bruna Velosa; Caetano, Joana; Barahona, Filipa; Carneiro, Emilie Arnault; João, CristinaFunding: This research was funded by Fundação para a Ciência e Tecnologia (FCT), PTDC/MECHEM/30315/2017 and UIDB/04443/2020; Despite the improvement of patient’s outcome obtained by the current use of immunomod-ulatory drugs, proteasome inhibitors or anti-CD38 monoclonal antibodies, multiple myeloma (MM) remains an incurable disease. More recently, the testing in clinical trials of novel drugs such as anti-BCMA...