3 documents found, page 1 of 1
BioMarrow
Lourenço, Diana; Lopes, Raquel; Caetano, Joana; Barahona, Filipa; Rodrigues, Jessica; Queirós, Ana C.; Carneiro, Emilie Arnault; João, CristinaPreclinical models for multiple myeloma (MM) often fail to recapitulate the complexity of the bone marrow (BM) microenvironment, limiting their utility for drug testing and translational research. There is an urgent need for physiologically relevant, patient-adaptable platforms to support personalized therapeutic evaluation. We developed BioMarrow, a 3D ex vivo BM culture system using unmanipulated patient BM a...
The immune microenvironment in multiple myeloma : friend or foe?
Lopes, Raquel; Caetano, Joana; Ferreira, Bruna; Barahona, Filipa; Carneiro, Emilie Arnault; João, CristinaMultiple myeloma (MM) is one of the most prevalent hematological cancers worldwide, characterized by the clonal expansion of neoplastic plasma cells in the bone marrow (BM). A combination of factors is implicated in disease progression, including BM immune microenvironment changes. Increasing evidence suggests that the disruption of immunological processes responsible for myeloma control ultimately leads to the...
Statistical methods for the study of extracellular vesicles content and their p...
Pestana, Carolina Festas; Sousa, Lisete; Carneiro, Emilie; Barahona, Filipa; Caetano, Joana; Lopes, Raquel; Ferreira, Bruna; João, Cristina