5 documents found, page 1 of 1
Self-assembly in nature : using the principles of nature to create complex nano...
Mendes, A. C.; Baran, Erkan Türker; Reis, R. L.; Azevedo, Helena S.Self-assembly is a ubiquitous process in biology where it plays numerous important roles and underlies the formation of a wide variety of complex biological structures. Over the past two decades, materials scientists have aspired to exploit nature’s assembly principles to create artificial materials, with hierarchical structures and tailored properties, for the fabrication of functional devices. Toward this goa...
Fabrication of phospholipid–xanthan microcapsules by combining microfluidics wi...
Mendes, A. C.; Baran, Erkan Türker; Reis, R. L.; Azevedo, Helena S.We report the synthesis of an amphiphilic polysaccharide, a phospholipid (1,2-dioleoyl-sn-glycerophosphoetilamine, DOPE) conjugated with the anionic xanthan gum, and its ability to spontaneously self-assemble under mild aqueous conditions. This work also aimed to apply a microfluidic platform that can precisely fabricate microsized and monodispersed capsules for cell encapsulation. Stable hollow capsular struct...
Encapsulation and survival of a chondrocyte cell line within xanthan gum deriva...
Mendes, Ana Carina; Baran, Erkan Türker; Pereira, Rui C.; Azevedo, Helena S.; Reis, R. L.A chemical derivative of xanthan gum polysaccharide is investigated as a new artificial matrix for the encapsulation of chondrocytic cells. Toward this goal, a novel micro-droplet generator is developed to produce microcapsules. Microcapsules with an average diameter of 500 mm, smooth surface, and homogeneous size distribution are obtained. ATDC5 cells encapsulated in carboxymethyl xanthan (CMX) microcapsules r...
Microchannel-patterned and heparin micro-contact-printed biodegradable composit...
Baran, Erkan Türker; Tuzlakoglu, K.; Salgado, A. J.; Reis, R. L.Microchannel-patterned starch–poly(capro-lactone)/hydydroxyapatite (SPCL–HA) and starch– poly(lactic acid) (SPLA) composite membranes were produced for use as a laminated tissueengineering scaffold that incorporates both physical and biochemical patterns. For this purpose, SPCL (30% starch) blended with inorganic hydroxyl apatite (50%) and SPLA (50% starch) membranes were made with compressive moulding. Consequ...
Palmitoylation of xanthan polysaccharide for self-assembly microcapsule formati...
Mendes, Ana Carina; Baran, Erkan Türker; Nunes, Cláudia; Coimbra, Manuel A.; Azevedo, Helena S.; Reis, R. L.Hydrophobized polysaccharides have emerged as a promising strategy in the biomedical field due to the versatility to design functional structures through the spontaneous self-assembly in cell-friendly conditions. Based on this concept, xanthan, a bacterial extracellular polysaccharide with potential as encapsulating matrix, was conjugated with hydrophobic palmitoyl groups to obtain an amphiphilic system able to...