5 documents found, page 1 of 1
Competition for endothelial cell polarity drives vascular morphogenesis in the ...
Barbacena, Pedro; Dominguez-Cejudo, Maria Angeles; Fonseca, Catarina; Gómez-González, Manuel; Faure, Laura M.; Zarkada, Georgia; Pena, AndreiaBlood-vessel formation generates unique vascular patterns in each individual. The principles governing the apparent stochasticity of this process remain to be elucidated. Using mathematical methods, we find that the transition between two fundamental vascular morphogenetic programs-sprouting angiogenesis and vascular remodeling-is established by a shift of collective front-to-rear polarity of endothelial cells ...
Endothelial cell invasion is controlled by dactylopodia
Figueiredo, Ana; Barbacena, Pedro; Russo, Ana; Vaccaro, Silvia; Ramalho, Daniela; Pena, Andreia; Lima, Aida Pires; Rua Ferreira, Rita; Fidalgo, MartaSprouting angiogenesis is fundamental for development and contributes to cancer, diabetic retinopathy, and cardiovascular diseases. Sprouting angiogenesis depends on the invasive properties of endothelial tip cells. However, there is very limited knowledge on how tip cells invade into tissues. Here, we show that endothelial tip cells use dactylopodia as the main cellular protrusion for invasion into nonvascular...
Endothelial cells on the move: dynamics in vascular morphogenesis and disease
Fonseca, Catarina; Barbacena, Pedro; Franco, ClaudioThe vascular system is a hierarchically organized network of blood vessels that play crucial roles in embryogenesis, homeostasis and disease. Blood vessels are built by endothelial cells - the cells lining the interior of blood vessels - through a process named vascular morphogenesis. Endothelial cells react to different biomechanical signals in their environment by adjusting their behavior to: (1) invade, prol...
Non-canonical Wnt signaling regulates junctional mechanocoupling during angioge...
Carvalho, Joana R.; Fortunato, Isabela C.; Fonseca, Catarina; Pezzarossa, Anna; Barbacena, Pedro; Dominguez-Cejudo, Maria AngelesMorphogenesis of hierarchical vascular networks depends on the integration of multiple biomechanical signals by endothelial cells, the cells lining the interior of blood vessels. Expansion of vascular networks arises through sprouting angiogenesis, a process involving extensive cell rearrangements and collective cell migration. Yet, the mechanisms controlling angiogenic collective behavior remain poorly underst...
Molecular mechanisms regulating endothelial cell axial polarity during vascular...
Barbacena, PedroThe establishment of a functional patterned vascular network is crucial for development, tissue growth and homeostasis. The mis-patterning or dysfunction of this network is associated with cancer, stroke and arteriovenous malformations. The formation of a functional vascular network requires two distinct processes – formation of primitive vascular plexuses through sprouting angiogenesis; and vascular remodellin...