15 documents found, page 1 of 2
Concordance between FVC and FEV<sub>6</sub> for identifying chronic airflow obs...
Knox-Brown, Ben; Potts, James; Franssen, Frits M. E.; Nielsen, Rune; Denguezli, Meriem; Rotevatn, Anders Ørskov; Juvekar, Sanjay K.Introduction: We investigated whether the forced expiratory volume in 6 s (FEV6) can be used as a surrogate for the forced vital capacity (FVC). Methods: The Burden of Obstructive Lung Disease is a multinational cohort study. At baseline, data were collected from adults aged 40 years or older, from 41 sites across 34 countries. Participants from 18 sites were followed up after a median of 8.3 years. Participant...
Geographical variation in lung function: results from the multicentric cross-se...
Burney, Peter G.; Potts, James; Knox-Brown, Ben; Erhabor, Gregory; Hacene Cherkaski, Hamid; Mortimer, Kevin; Anand, Mahesh Padukudru; Mannino, David M.Spirometry is used to determine what is "unusual" lung function compared with what is "usual" for healthy non-smokers. This study aimed to investigate regional variation in the forced vital capacity (FVC) and in the forced expiratory volume in one second to FVC ratio (FEV1/FVC) using cross-sectional data from all 41 sites of the multinational Burden of Obstructive Lung Disease study. Participants (5,368 men; 9,...
Prevalence of chronic cough, its risk factors and population attributable risk ...
Abozid, Hazim; Patel, Jaymini; Burney, Peter; Hartl, Sylvia; Breyer-Kohansal, Robab; Mortimer, Kevin; Nafees, Asaad A.; Al Ghobain, MohammedBackground: Chronic cough is a common respiratory symptom with an impact on daily activities and quality of life. Global prevalence data are scarce and derive mainly from European and Asian countries and studies with outcomes other than chronic cough. In this study, we aimed to estimate the prevalence of chronic cough across a large number of study sites as well as to identify its main risk factors using a stan...
Patient-centered digital biomarkers for allergic respiratory diseases and asthm...
Bousquet, Jean; Shamji, Mohamed H.; Anto, Josep M.; Schünemann, Holger J.; Canonica, G. Walter; Jutel, Marek; Del Giacco, Stefano; Zuberbier, TorstenBiomarkers for the diagnosis, treatment and follow-up of patients with rhinitis and/or asthma are urgently needed. Although some biologic biomarkers exist in specialist care for asthma, they cannot be largely used in primary care. There are no validated biomarkers in rhinitis or allergen immunotherapy (AIT) that can be used in clinical practice. The digital transformation of health and health care (including mH...
Small airways obstruction and its risk factors in the Burden of Obstructive Lun...
Knox-Brown, Ben; Patel, Jaymini; Potts, James; Ahmed, Rana; Aquart-Stewart, Althea; Cherkaski, Hamid Hacene; Denguezli, Meriam; Elbiaze, MohammedBackground: Small airway obstruction is a common feature of obstructive lung diseases. Research is scarce on small airway obstruction, its global prevalence, and risk factors. We aimed to estimate the prevalence of small airway obstruction, examine the associated risk factors, and compare the findings for two different spirometry parameters. Methods: The Burden of Obstructive Lung Disease study is a multination...
Shotgun proteomics of red blood cells from obstructive sleep apnea patients und...
Coelho, Cristina Valentim; Osório, Hugo; Vaz, Fatima; Neves, Sofia; Pinto, Paula; Barbara, Cristina; Penque, DeborahObstructive Sleep Apnea (OSA) syndrome is characterized by recurrent episodes of apneas and hypopneas during sleep, leading to recurrent intermittent hypoxia and sleep fragmentation. No treated OSA can result in metabolic and cardiovascular diseases. By 2D gel-based proteomics approach we have demonstrated that OSA can cause alterations in the red blood cells (RBC) proteome that may be associated with OSA outco...
Chronic airflow obstruction and ambient particulate air pollution
Amaral, Andre F.; Burney, Peter G.; Patel, Jaymini; Minelli, Cosetta; Mejza, Filip; Mannino, David M.; Seemungal, Terence A.; Mahesh, Padukudru AnandSmoking is the most well-established cause of chronic airflow obstruction (CAO) but particulate air pollution and poverty have also been implicated. We regressed the sex-specific prevalence of CAO from 41 Burden of Obstructive Lung Disease study sites against smoking prevalence from the same study, the gross national income per capita, and the local annual mean level of ambient particulate matter (PM2.5) using ...
Effects of positive airway pressure therapy on red blood cells in patients with...
Coelho-Valentim, Cristina; Vaz, Fátima; Barbara, Cristina; Penque, DeborahIntroduction: Obstructive Sleep Apnea (OSA) syndrome is characterized by recurrent arousals from sleep and intermittent hypoxemia. We recently demonstrated that OSA can cause alterations in the red blood cells (RBC) proteome that may be associated with OSA outcomes. Here we intend to investigate whether the positive airway pressure (PAP) treatment can revert/modulate these proteome alterations.
Diabetes mellitus tipo 2 (DMT2) associada a Sindrome de Apneia Obstrutiva do So...
Vaz, Fátima; Valentim-Coelho, Cristina; Neves, Sofia; Penque, Deborah; Barbara, CristinaIntrodução: A prevalência da SAOS é elevada em doentes com DMT2. O não tratamento da SAOS pode levar ao agravamento ou desenvolvimento da DMT2. Temos vindo a demonstrar que a SAOS altera o proteoma do glóbulo vermelho (GV). A SAOS aumenta a overoxidação da peroxirredoxina 2 (PRDX2) (enzima antioxidante), o que pode levar à desregulação da homeostasia do GV e ao desenvolvimento de doenças metabólicas. Após trata...
Obstructive sleep apnea associated with Diabetes mellitus Type 2: a proteomic s...
Vaz, Fátima; Valentim-Coelho, Cristina; Neves, Sofia; Feliciano, Amelia; Antunes, Marília; Pinto, Paula; Barbara, Cristina; Penque, DeborahBackground: We previously showed that Obstructive sleep apnea (OSA), a common public health concern causing deleterious cardiometabolic dysfunction, induced proteomic alterations in red blood cells (RBC) such as changes in the redox-oligomeric state of peroxiredoxin 2 (PRDX2)1-2. Herein, we aimed to investigate whether OSA patients with Type 2 Diabetes Mellitus before and after positive airway pressure (PAP) tr...