Encontrados 6 documentos, a visualizar página 1 de 1
Aldehyde Dehydrogenase 2 (ALDH2)
Ferreira, Inês C.; Torrejón, Estefania; Abecasis, Bernardo; Alexandre, Bruno M.; Gomes, Ricardo A.; Verslype, Chris; van Pelt, Jos; Barbas, AnaFunding Information: We thank UniMS–Mass Spectrometry Unit from ITQB/iBET (Oeiras, Portugal) for MS data acquisition, and particular to Patrícia Alves, Ana Guerreiro and Catarina Correia for discussions and technical support on mass spectrometry. We thank Pedro Lamosa for discussions and technical support on NMR. We also thank Joerg Bomke, Pedro Sousa, Carolina Cassona, Inês Isidro and Inês Carrondo for fruitfu...
Novel scFv against Notch Ligand JAG1 Suitable for Development of Cell Therapies...
Silva, Gabriela; Rodrigues, Ana F.; Ferreira, Susana; Matos, Carolina; Eleutério, Rute P.; Marques, Gonçalo; Kucheryava, Khrystyna; Lemos, Ana R.Funding Information: This research was funded by the Fundação para a Ciência e Tecnologia/Ministério da Ciência, Tecnologia e Ensino Superior (FCT/MCTES, Portugal) grant PTDC/BBB-BMD/4497/2014 (to A.B.), through national funds to iNOVA4Health (UIDB/04462/2020 and UIDP/04462/2020), and the Associate Laboratory LS4FUTURE (LA/P/0087/2020). Publisher Copyright: © 2023 by the authors.; The Notch signaling ligand JAG...
Development of Dl1.72, a novel anti-DLL1 antibody with anti-tumor efficacy agai...
Silva, Gabriela; Sales-Dias, Joana; Casal, Diogo B.; Alves, Sara; Domenici, Giacomo; Barreto, Clara; Matos, Carolina; Lemos, Ana R.; Matias, Ana T.Funding Information: Funding: This research was funded by Fundação para a Ciência e Tecnologia, Portugal, grants PTDC/BBB-BMD/4497/2014 (to A.B.) and PD/BD/113987/2015 (to J.S.-D.), iBETXplore grants 3D-ABC-PI-717 (to G.D.) and BiACaT-HER2:JAG1 (to G.S.). iNOVA4Health—UIDB/04462/2020 and UIDP/04462/2020, a program financially supported by Fundação para a Ciência e Tecnolo-gia/Ministério da Ciência, Tecnologia e...
The Notch ligand DLL1 exerts carcinogenic features in human breast cancer cells
Sales-Dias, Joana; Silva, Gabriela; Lamy, Márcia; Ferreira, Andreia; Barbas, AnaBreast cancer (BC) is the most common type of cancer in women and has a high rate of relapse and death. Notch signaling is crucial for normal breast development and homeostasis. Dysregulation of Notch receptors and ligands has been detected in different BC subtypes and shown to be implicated in tumor development, progression, drug resistance, and recurrence. However, the effects of Notch ligands in various type...
Novel monoclonal antibody L2A5 specifically targeting sialyl-Tn and short glyca...
Loureiro, Liliana R.; Sousa, Diana P.; Ferreira, Dylan; Chai, Wengang; Lima, Luís Carlos Oliveira; Pereira, Carina; Lopes, Carla B.; Correia, Viviana G.This work was supported by the Bluepharma innovation award "Trifunctional antibodies and dendritic cell-based technologies: a combined approach to cancer immunotherapy" 2013 and the Scientific merit prize Santander - Totta - Lisbon New University - "Antibody engineering for breast cancer therapy" 2013. LRL is supported by the grant PD/BD/52476/2013 from the Portuguese Foundation for Science and Technology (FCT)...
Challenges in Antibody Development against Tn and Sialyl-Tn Antigens
Loureiro, Liliana R; Carrascal, Mylène A; Barbas, Ana; Ramalho, José S; Novo, Carlos; Delannoy, Philippe; Videira, Paula APMID: 26270678 PMCID:4598775; The carbohydrate antigens Tn and sialyl-Tn (STn) are expressed in most carcinomas and usually absent in healthy tissues. These antigens have been correlated with cancer progression and poor prognosis, and associated with immunosuppressive microenvironment. Presently they are used in clinical trials as therapeutic vaccination, but with limited success due to their low immunogenicity...