3 documents found, page 1 of 1
Inhibition of human immunodeficiency virus type 1 replication with artificial t...
Eberhardy, SR; Goncalves, J; Coelho, S; Segal, DJ; Berkhout, B; Barbas, CFThe human immunodeficiency virus type 1 (HIV-1) primer-binding site (PBS) is a highly conserved region in the HIV genome and represents an attractive target for the development of new anti-HIV therapies. In this study, we designed four artificial zinc fin
Intrabodies targeting the Kaposi sarcoma-associated herpesvirus latency antigen...
Corte-Real, S; Collins, C; da Silva, FA; Simas, JP; Barbas, CF; Chang, Y; Moore, P; Goncalves, JKaposi sarcoma-associated herpesvirus (KSHV) latency-associated nuclear antigen-1 (LANA1) is essential for the maintenance and segregation of viral episomes in KSHV latently infected B cells. We report development of intracellular, rabbit-derived antibodi
Attenuation of HIV-1 replication in primary human cells with a designed zinc fi...
Segal, DJ; Goncalves, J; Eberhardy, S; Swan, CH; Torbett, BE; Li, XL; Barbas, CFSmall molecule inhibitors of human immunodeficiency virus, type 1 (HIV-1) have been extremely successful but are associated with a myriad of undesirable effects and require lifelong daily dosing. In this study we explore an alternative approach, that of i