3 documents found, page 1 of 1
Allergic inflammation triggers dyslipidemia via IgG signalling
Fernández-Gallego, Nieves; Castillo-González, Raquel; Moreno-Serna, Lucía; García-Cívico, Antonio J.; Sánchez-Martínez, Elisa; López-Sanz, CeliaBackground: Allergic diseases begin early in life and are often chronic, thus creating an inflammatory environment that may precede or exacerbate other pathologies. In this regard, allergy has been associated to metabolic disorders and with a higher risk of cardiovascular disease, but the underlying mechanisms remain incompletely understood. Methods: We used a murine model of allergy and atherosclerosis, differ...
Allergic inflammation triggers dyslipidemia via IgG signalling
Fernández-Gallego, Nieves; Castillo-González, Raquel; Moreno-Serna, Lucía; García-Cívico, Antonio J.; Sánchez-Martínez, Elisa; López-Sanz, CeliaAllergic diseases begin early in life and are often chronic, thus creating an inflammatory environment that may lead to metabolic disorders, although the underlying mechanisms remain incompletely understood. Here, we show that allergic inflammation induces diet-independent dyslipidemia in a mouse model of allergy and atherosclerosis. Using untargeted lipidomics in mouse plasma, we found that allergic inflammati...
EAACI molecular allergology user's guide 2.0
Dramburg, Stephanie; Hilger, Christiane; Santos, Alexandra F.; de las Vecillas, Leticia; Aalberse, Rob C.; Acevedo, Nathalie; Aglas, LorenzSince the discovery of immunoglobulin E (IgE) as a mediator of allergic diseases in 1967, our knowledge about the immunological mechanisms of IgE-mediated allergies has remarkably increased. In addition to understanding the immune response and clinical symptoms, allergy diagnosis and management depend strongly on the precise identification of the elicitors of the IgE-mediated allergic reaction. In the past four...