2 documents found, page 1 of 1
In vivo systemic toxicity assessment of an oxidized dextrin-based hydrogel and ...
Pereira, I; Fraga, S; Maltez, L; Requicha, J; Guardão, L; Oliveira, J; Prada, J; Alves, H; Santos, JD; Teixeira, JP; Pereira, JE; Soares, R; Gama, FMThe worldwide incidence of bone disorders is raising, mainly due to aging population. The lack of effective treatments is pushing the development of synthetic bone substitutes (SBSs). Most ceramic-based SBSs commercially available display limited handling properties. Attempting to solve these issues and achieve wider acceptance by the clinicians, granular ceramics have been associated with hydrogels (HGs) to pr...
Excess perigestational folic acid exposure induces metabolic dysfunction in pos...
Keating, E; Correia-Branco, A; Araújo, JR; Meireles, M; Fernandes, R; Guardão, L; Guimarães, JT; Martel, F; Calhau, CThe aim of this study was to understand whether high folic acid (HFA) exposure during the perigestational period induces metabolic dysfunction in the offspring, later in life. To do this, female Sprague-Dawley rats (G0) were administered a dose of folic acid (FA) recommended for pregnancy (control, C, 2 mg FA/kg of diet, n=5) or a high dose of FA (HFA, 40 mg FA/kg of diet, n=5). Supplementation began at mating ...