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Recent advances in nanomaterial-based optical biosensors for food safety applic...

Meira, Diana I.; Barbosa, Ana Isabel Ferreira; Borges, Joel; Reis, R. L.; Correlo, V. M.; Vaz, Filipe

Global population growth tremendously impacts the global food industry, endangering food safety and quality. Mycotoxins, particularly Ochratoxin-A (OTA), emerge as a food chain production threat, since it is produced by fungus that contaminates different food species and products. Beyond this, OTA exhibits a possible human toxicological risk that can lead to carcinogenic and neurological diseases. A selective, ...


Chitosan micro-membranes with integrated gold nanoparticles as an LSPR-based se...

Meira, Diana Isabela Faria; Proença, Maria Manuela Carvalho; Rebelo, Rita Daniela Nogueira; Barbosa, Ana Isabel Ferreira; Rodrigues, Marco S.

Currently, there is an increasing need to develop highly sensitive plasmonic sensors able to provide good biocompatibility, flexibility, and optical stability to detect low levels of analytes in biological media. In this study, gold nanoparticles (Au NPs) were dispersed into chitosan membranes by spin coating. It has been demonstrated that these membranes are particularly stable and can be successfully employed...


An outlook on implantable biosensors for personalized medicine

Rebelo, Rita; Barbosa, Ana Isabel Ferreira; Correlo, V. M.; Reis, R. L.

Biosensors are a fast-growing field, as they have been shown to be very helpful in our daily life, playing roles in industries such as agriculture, food safety, homeland security, bioprocessing, environmental monitoring, and industrial monitoring. Beyond these, the application of biosensing in medicine and biomedical engineering may have the highest potential for growth and for affecting human quality of life i...


Current nanotechnology advances in diagnostic biosensors

Barbosa, Ana Isabel Ferreira; Rebelo, Rita Daniela Nogueira; Reis, R. L.; Bhattacharya, M.; Correlo, V. M.

Current diagnostics present challenges that are imposed by increased life expectancy in the worldwide population. These challenges are related, not only to satisfy the need for higher performance of diagnostic tests, but also to the capacity of creating pointâ ofâ care, wearable, multiplexing and implantable diagnostic platforms that will allow early detection, continuous monitoring and treatment of health cond...


Development of label-free plasmonic Au-TiO2 thin film immunosensor devices

Barbosa, Ana Isabel Ferreira; Borges, Joel Nuno Pinto; Meira, Diana Isabela Faria; Costa, Diogo Emanuel Carvalho; Rodrigues, Marco S.

This work reports on the development of a label-free immunosensor technology, based on nanoplasmonic Au-TiO2 thin films. The Au-TiO2 thin films were prepared by cost-effective reactive DC magnetron sputtering, followed by a thermal annealing procedure. The latter promoted the growth of the Au nanoparticles throughout the TiO2 matrix and induced some morphological changes, which are the base for the immunosensor...


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