9 documents found, page 1 of 1
Candida albicans chitinase 3 with potential as a vaccine antigen: production, p...
Barbosa, Augusto Alexandre Costa; Ferreira, Diogo; Pacheco, Maria Inês; Casal, Margarida; Duarte, Henrique Oliveira; Gomes, CatarinaChitinases are widely studied enzymes that have already found widespread application. Their continued development and valorisation will be driven by the identification of new and improved variants and/or novel applications bringing benefits to industry and society. We previously identified a novel application for chitinases wherein the Candida albicans cell wall surface chitinase 3 (Cht3) was shown to have pote...
Microbiota regulation of cancer immune surveillance
Barbosa, Ana Margarida MartinsO cancro representa um dos principais problemas de saúde a nível mundial, prevendo-se um aumento da sua incidência nos próximos anos. Embora o desenvolvimento de novas terapias tenha reduzido a mortalidade, é crucial determinar novos alvos terapêuticos para tratar os pacientes que não respondem aos tratamentos existentes. Assim, torna-se indispensável definir os principais intervenientes envolvidos na carcinogé...
Increased CD3+, CD8+, or FoxP3+ T lymphocyte infiltrations are associated with ...
Barbosa, Ana Margarida Martins; Martinho, Olga; Cardoso, Rosete Maria Amorim Novais Nogueira; Campos, Juliana; Lobo, Liliana; Pinto, HenriqueTumor-infiltrating lymphocytes include heterogeneous populations of T lymphocytes that play crucial roles in the tumor immune response; importantly, their presence in the tumor tissue may predict clinical outcomes. Therefore, we herein studied the prognostic significance of the presence and location of CD3<sup>+</sup>, CD8<sup>+</sup>, and FoxP3<sup>+</sup> T lymphocytes in colorectal cancer samples. In the int...
Optimization of silver-containing bioglass nanoparticles envisaging biomedical ...
Vale, A. Catarina; Pereira, Paulo R.; Barbosa, Ana Margarida Martins; Torrado, Egídio; Alves, N. M.Bioglass nanoparticles (BGs) are of outmost importance in the biomedical field, because their unique characteristics, namely osteoconductivity and osteoinductivity, and also in certain conditions, angiogenic and bactericidal properties. In this work, novel bioglass nanoparticles containing silver (AgBGs) were synthesized by a sol-gel method, adopting different thermal treatments to obtain new nanoparticles with...
Antibacterial free-standing polysaccharide composite films inspired by the sea
Vale, A. Catarina; Pereira, Paulo R.; Barbosa, Ana Margarida Martins; Torrado, Egídio; Mano, J. F.; Alves, N. M.The adhesive capabilities of marine mussel proteins are well-known, exhibiting the ability to stick to different underwater substrates, either inorganic or organic. These unique adhesive properties are due to the high levels of amino acid, 3,4-dihydroxyphenyl-l-alanine (DOPA), which presents the reactive catechol group. Herein, novel antibacterial free-standing (FS) films were developed with natural polymers, n...
Immune-evasion strategies of mycobacteria and their implications for the protec...
Fraga, Alexandra G.; Barbosa, Ana Margarida Martins; Ferreira, Catarina Machado; Fevereiro, João; Pedrosa, Jorge; Torrado, EgídioMycobacteria are intracellular pathogens that have macrophages as their main host cells. However, macrophages are also the primary line of defense against invading microorganisms. To survive in the intracellular compartment, virulent mycobacteria have developed several strategies to modulate the activation and the effector functions of macrophages. Despite this, antigen-specific T cells develop during infection...
Novel antibacterial and bioactive silicate glass nanoparticles for biomedical a...
Vale, Ana Catarina; Carvalho, Ana Luísa; Barbosa, Ana Margarida Martins; Torrado, Egídio; Mano, J. F.; Alves, N. M.In this work, the authors propose a new quick sol–gel procedure for bioglass nanoparticles production containing 10% mol of silver (AgBGs). These new AgBGs are characterized by Zeta potential analysis, scanning electron microscopy with X-ray microanalysis (SEM/EDS), X-ray powder diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), and microbiological tests to confirm their bioactive and antibacter...
HER Family Receptors are Important Theranostic Biomarkers for Cervical Cancer: ...
Martinho, Olga; Silva-Oliveira, Renato; Barbosa, Ana Margarida Martins; Granja, Sara Costa; Miranda-Gonçalves, Vera; Cardoso-Carneiro, DianaPersistent HPV infection alone is not sufficient for cervical cancer development, which requires additional molecular alterations for tumor progression and metastasis ultimately leading to a lethal disease. In this study, we performed a comprehensive analysis of HER family receptor alterations in cervical adenocarcinoma. We detected overexpression of HER protein, mainly HER2, which was an independent prognostic...
The role of IL-10 in the immune response to cancer
Barbosa, Ana Margarida MartinsDuring tumor development, tumor cells interact with their microenvironment where the immune contexture shapes their fate. There is now a growing body of evidence that the tumor microenvironment, which is mainly orchestrated by immune cells, is a critical participant in the neoplastic process, fostering tumor proliferation, survival and metastasis. Inflammatory cells, including tumor associated macrophages (TAMs...