3 documents found, page 1 of 1
A sulfated-polysaccharide fraction from seaweed gracilaria birdiae prevents nap...
Silva, Renan O.; Santana, Ana Paula M.; Carvalho, Nathalia S.; Bezerra, Talita S.; Oliveira, Camila B.; Damasceno, Samara Rodrigues BonfimAbstract: Red seaweeds synthesize a great variety of sulfated galactans. Sulfated polysaccharides (PLSs) from seaweed are comprised of substances with pharmaceutical and biomedical potential. The aim of the present study was to evaluate the protective effect of the PLS fraction extracted from the seaweed Gracilaria birdiae in rats with naproxen-induced gastrointestinal damage. Male Wistar rats were pretreated w...
Carvacryl acetate, a derivative of carvacrol, reduces nociceptive and inflammat...
Damasceno, Samara Rodrigues Bonfim; Oliveira, Francisco Rodrigo A.M.; Carvalho, Nathalia S.; Brito, Camila F.C.; Silva, Irismara S.Aims: The present study aimed to investigate the potential anti-inflammatory and anti-nociceptive effects of carvacryl acetate, a derivative of carvacrol, in mice. Main methods: The anti-inflammatory activity was evaluated using various phlogistic agents that induce paw edema, peritonitis model, myeloperoxidase (MPO) activity, pro and anti-inflammatory cytokine levels. Evaluation of antinociceptive activity was...
Oral gabapentin treatment accentuates nerve and peripheralinflammatory response...
Câmara, Carlos C.; Ramos, Heitor F.; Silva, Alan P. da; Araújo, Celina V.; Gomes, Antoniella Souza; Vale, Mariana L.; Barbosa, André Luiz R.Gabapentin (GBP) is an anti-convulsive drug often used as analgesic to control neuropathic pain. Thisstudy aimed at evaluating whether oral GBP treatment could improve nerve inflammation response aftersciatic nerve constriction in association with selected pain and motor spontaneous behavior assessmentsin Wistar rats. We evaluated nerve myeloperoxidase (MPO) and inflammatory cytokines on the 5th daypost-injury,...