Seeds of Acacia farnesiana are commonly sold in the local markets of northeastern Brazil as a therapeutic agent. The present work aimed to evaluate the anti-inflammatory and analgesic activities of proteins obtained from A. farnesiana seeds. Five different protein fractions (albumin, globulin, prolamin, acidic and basic glutelins) were obtained and investigated for the protein pattern, the presence of hemagglut...
Objectives The aim of this study was to evaluate the anti-inflammatory effect of a sulphated polysaccharide fraction (PLS) extracted from the alga Hypnea musciformis and investigate the possible involvement of the nitric oxide (NO) pathway in this effect. Methods The anti-inflammatory activity of PLS was evaluated using inflammatory agents (carrageenan and dextran) to induce paw oedema and peritonitis in Swiss ...
Objective: To determine the prevalence of dysmenorrhea in female university students and the frequency of school absenteeism, physical exercise and use of medicines to treat the syndrome. Methods: This is a cross-sectional study conducted with university students using a self-administered questionnaire containing sociodemographic, obstetrical, and gynecological data. The menstrual pain was assessed by the visua...
Our objective was to evaluate the effect of the 256 Walker carcinossarcoma inoculation, as well as the time course of tumoral development, upon the acute inflammatory response in rats. Wistar rats, 180-220g, received intramuscular 106 tumor cells injections. At the end of 4, 7 or 10 days, wistar rats were separated into 4 groups, with 6 animals per group. The control group, were not inoculated with tumoral cell...
The aim of this study was to investigate a possible involvement of the opioids, endocannabinoids and NO/cGMP/PKG/K+ATP pathway in the antinociception of the Crohn´s experimental model in hypernociception induced by carragenan ou PGE2. Colitis was induced in the male Wistar rats (200-250) by intracolonic administration of 20 mg of 2,4,6-trinitrobenzene sulfonic acid (TNBS) in 50% ethanol, ethanol 50% or an equiv...