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Combined study of ADAMTS13 and complement genes in the diagnosis of thrombotic ...

Fidalgo, Teresa; Martinho, Patrícia; Pinto, Catarina S.; Oliveira, Ana C.; Salvado, Ramon; Borràs, Nina; Coucelo, Margarida; Manco, Licínio

Background: The 2 main forms of thrombotic microangiopathy (TMA) are thrombotic thrombocytopenic purpura (TTP) and atypical hemolytic uremic syndrome (aHUS). Deficiency of ADAMTS13 and dysregulation of the complement pathway result in TTP and aHUS, respectively; however, overlap of their clinical characteristics makes differential diagnosis challenging. Objectives and Methods: We aimed to develop a TMA diagnosi...

Date: 2017   |   Origin: Estudo Geral - Universidade de Coimbra
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Familial thrombotic risk based on the genetic background of Protein C Deficienc...

Fidalgo, Teresa; Martinho, Patrícia; Salvado, Ramon; Manco, Licínio; Oliveira, Ana C.; Pinto, Catarina S.; Gonçalves, Elsa; Marques, Dalila

Date: 2015   |   Origin: Estudo Geral - Universidade de Coimbra
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