2 documents found, page 1 of 1
The antioxidant peptide salamandrin-i: First bioactive peptide identified from ...
Plácido, A; Bueno, J; Barbosa, EA; Moreira, DC; Dias, JDN; Cabral, WF; Albuquerque, P; Bessa, LJ; Freitas, J; Kuckelhaus, SAS; Lima, FCDAAmphibian skin is a multifunctional organ that plays key roles in defense, breathing, and water balance. In this study, skin secretion samples of the fire salamander (Salamandra salamandra) were separated using RP-HPLC and de novo sequenced using MALDI-TOF MS/MS. Next, we used an in silico platform to screen antioxidant molecules in the framework of density functional theory. One of the identified peptides, sal...
Novel Ocellatin Peptides Mitigate LPS-induced ROS Formation and NF-kB Activatio...
Sousa, NA; Oliveira, GAL; Oliveira, AP; Lopes, ALF; Iles, B; Nogueira, KM; Araújo, TSL; Souza, LKM; Araújo, AR; Ramos-Jesus, J; Plácido, A; Amaral, CCutaneous secretions of amphibians have bioactive compounds, such as peptides, with potential for biotechnological applications. Therefore, this study aimed to determine the primary structure and investigate peptides obtained from the cutaneous secretions of the amphibian, Leptodactylus vastus, as a source of bioactive molecules. The peptides obtained possessed the amino acid sequences, GVVDILKGAAKDLAGH and GVV...