164 documents found, page 1 of 17
MDMA and tramadol or tapentadol co-administration causes serotonin-independent ...
Faria, Juliana; Barbosa, Joana; Queirós , Odília; Dinis-Oliveira , Ricardo JorgeThe simultaneous consumption and misuse of different drugs, including 3,4-methylenedioxymethamphetamine (MDMA, “ecstasy”) and opioids, raise concerns about fatal intoxications, as a result of increased serotonin levels. However, research on the simultaneous consumption of MDMA and opioids is limited. This study aimed to evaluate the toxic effect of the simultaneous exposure of the undifferentiated human SH-SY5Y...
Cebranopadol, a first-in-class investigational opioid: Insights from preliminar...
Almeida, Margarida; Diogo , Beatriz; Rocha , Joana; Dinis-Oliveira , Ricardo Jorge; Cunha , Andrea; Faria , Juliana; Barbosa, JoanaBackground: Cebranopadol, a promising opioid analgesic undergoing phase III trials, was developed for the treatment of acute and chronic moderate-to-severe pain. Because it is a non-selective ligand acting at more than one member of the opioid receptor family, combining a dual agonist action on mu-, delta-, and kappa-opioid receptors (MOR, DOR, and KOR) and nociceptin/orphanin FQ peptide (NOP) receptors, it has...
Impact of fermentation on the antioxidant activity and color of haematococcus p...
Bassani, Joseane C.; Martins, Valter; Barbosa, Joana; Steffens, Juliana; Backes, Geciane T.; Pereira, Hugo; Pintado, Manuela E.; Morais, Alcina M. M. B.Microalgae are emerging as a promising ingredient for the food industry due to their sustainable cultivation and production of a variety of bioactive compounds, including proteins, lipids, carbohydrates, antioxidant compounds, and pigments [1]. Among the many cataloged species of microalgae, two stand out in research due to their powerful applications in the pharmaceutical, nutraceutical, cosmetic, and food and...
Impact of polysorbate 80 on the antimicrobial activity of oregano and thyme
Carvalho, Marta; Barbosa, Joana; Silva, Marcelo Belchior Rosendo da; Albano, Helena; Teixeira, PaulaPlant-derived essential oils (EOs) possess significant antimicrobial potential against spoilage and pathogenic microorganisms. However, their efficacy can vary depending on the test method, making it difficult to standardise results. This study aimed to investigate the effect of polysorbate 80, a common surfactant used to emulsify EOs, on antimicrobial activity and minimum inhibitory concentration (MIC) determi...
Exploring the development of a clean-label vegan burger enriched with fermented...
Bassani, Joseane C.; Martins, Valter F. R.; Barbosa, Joana; Coelho, Marta; Sousa, Clara; Steffens, Juliana; Backes, Geciane T.; Pereira, HugoHaematococcus pluvialis and Porphyridium cruentum are red microalgae with high biotechnological potential due to their rich composition of bioactive compounds. However, their intense flavor limits their application in food products. This study evaluated the impact of fermentation with Lactiplantibacillus plantarum (30 ?C for 48 h; LAB-to-biomass ratio of 0.1:1; 106 CFU/mL) on the physicochemical and functional ...
Noite Europeia dos Investigadores em Armamar: uma história contada a várias vozes
Branquinho, Raquel; Duarte, Joaquim; Sarabando, Cândida; Damião, Cláudia; Duarte, Inês; Friães, Sofia; Lúcio, Marlene; Santos Carvalho, AnaA primeira edição da Noite Europeia dos Investigadores em Ambientes Rurais – Armamar (NEI-Armamar 2023) marcou um passo importante na promoção da cultura científica neste território rural. Este evento integrou o consórcio internacional SCIEVER – “Ciência para todos: sustentabilidade e inclusão” e demonstrou como a ciência pode ser uma ferramenta poderosa para democratizar o conhecimento, fortalecer o desenvolvi...
Development of functional chocolate incorporating Akkermansia muciniphila: the ...
Vedor, Rita; Machado, Daniela; Barbosa, Joana; Andrade, José C.; Gomes, Ana M.Objective: This study evaluated the feasibility of using chocolate as a food matrix for delivering Akkermansia muciniphila, a next- generation probiotic known for improving gut barrier function and metabolic health. The research assessed the viability of A. muciniphila in three different chocolate formulations, characterised the chocolate’s biological characteristics, and evaluated the potential prebiotic and b...
Exploring the development of a clean-label vegan burger enriched with fermented...
Bassani, Joseane C.; Martins, Valter F. R.; Barbosa, Joana; Coelho, Marta; Sousa, Clara; Steffens, Juliana; Backes, Geciane T.; Pereira, HugoHaematococcus pluvialis and Porphyridium cruentum are red microalgae with high biotechnological potential due to their rich composition of bioactive compounds. However, their intense flavor limits their application in food products. This study evaluated the impact of fermentation with Lactiplantibacillus plantarum (30 ◦C for 48 h; LAB-to-biomass ratio of 0.1:1; 106 CFU/mL) on the physicochemical and functional ...
The effect of slight pH changes in gastric conditions on the survival of Lister...
Oliveira, Mónica; Barbosa, Joana; Teixeira, PaulaIntroduction and Objectives: Listeria monocytogenes, the etiological agent of human listeriosis, poses a substantial threat as a lethal intracellular pathogen after the consumption of contaminated foods[1]. Invasive listeriosis is particularly severe in vulnerable populations, including pregnant women, newborns, the elderly, and immunocompromised individuals[2]. While all strains are conventionally considered e...
Lactic acid bacteria isolated from traditional and innovative alheiras as poten...
Azevedo, Inês; Barbosa, Joana; Albano, Helena; Nogueira, Teresa; Teixeira, PaulaFrom a selection of seven traditional and 14 innovative alheiras, 491 lactic acid bacteria (LAB) were isolated and tested for their antimicrobial activity against several food-borne pathogens. Among these, six strains revealed antimicrobial activity through potential bacteriocin production against 14 Listeria monocytogenes strains, Enterococcus faecalis ATCC 29212, Clostridium sporogenes ESB050, and Clostridium...