3 documents found, page 1 of 1
INJECTABLE HYBRID SYSTEM FOR STRONTIUM LOCAL DELIVERY TO PROMOTE BONE REGENERATION
Lourenço, A.H.; Machado, A,; Neves, N.; Alexandre, N.; Lamghari, M.; Barrias, C.C.; Barbosa, M.A.; Ribeiro, C,In bone tissue regeneration strategies, injectable bone substitutes are very attractive since they can be applied with minimally invasive surgical procedures and can perfectly fill irregular defects created in cases of trauma, infection or tumor resection. These materials must combine adequate mechanical properties with the ability to induce new bone formation. Incorporating strontium (Sr) in bone substitute bi...
IN VIVO STUDY OF THE EFFECT OF A STRONTIUM-‐RICH INJECTABLE SYSTEM ON BONE REG...
Machado, C.; Lourenço, A.H.; Neves, N.; Alexandre, Nuno; Lamghari, M.; Cabral, A.T.; Barbosa, M.A.; Ribeiro, C.C.Bone has the capacity to regenerate as part of the repair process,being newly formed boné indistinguishable from the adjacente uninjured bone. However,there are cases in which boné regeneration is required in large quantity, beyond the normal potential for self-‐healing, such as for lesions caused by trauma, infection, tumour resection or cases in which the regenerative process is compromised such as avascular...
Calcium phosphate-alginate microspheres as enzyme delivery matrices
Ribeiro, Cristina C.; Barrias, C.C.; Barbosa, M.A.The present study concerns the preparation and initial characterisation of novel calcium titanium phosphate-alginate (CTPalginate) and hydroxyapatite-alginate (HAp-alginate) microspheres, which are intended to be used as enzyme delivery matrices and bone regeneration templates. Microspheres were prepared using different concentrations of polymer solution (1% and 3% w/v) and different ceramic-to-polymer solution...