18 documents found, page 1 of 2
Circulating micrornas correlate with multiple myeloma and skeletal osteolytic l...
Moura, SR; Abreu, H; Cunha, C; Ribeiro-Machado, C; Oliveira, CM; Barbosa, MA; Marques, H; Almeida, MIMultiple myeloma (MM) is the second most frequent hematological disease and can cause skeletal osteolytic lesions. This study aims to evaluate the expression of circulating microRNAs (miR-NAs) in MM patients and to correlate those levels with clinicopathological features, including bone lesions. A panel of miRNAs associated with MM onset and progression, or with bone remodeling, was analyzed in the plasma of 82...
Alkaline phosphatase dual-binding sites for collagen dictate cell migration and...
Susana Guerreiro; Unger, RE; Cerqueira, NMFSA; Sartoris, A; Martins, MJ; Barbosa, MA; Soares, R; Granja, PL; Kirkpatrick, CJInteractions between cell types, growth factors, and extracellular matrix components involved in angiogenesis are crucial for new vessel formation leading to tissue regeneration. This study investigated whether cocultures of fibroblasts and endothelial cells (ECs; from macro- or microvasculature) play a role in the formation of microvessel-like structures by ECs, as well as modulate fibroblast differentiation a...
Immunomodulatory properties of Musa paradisiaca L. inflorescence in Combined Al...
Gadelha, FAAF; Cavalcanti, RFP; Vieira, GC; Ferreira, LKDP; Sousa, GR; Filho, JMB; Barbosa, MA; Santos, SG; Piuvezam, MRMusa paradisiaca L. (Musaceae), a tropical plant named banana is used as food and as medicine in Brazil. Banana inflorescence, popularly known as mangará, presents several biological activities including anti-inflammatory effects. Here, we demonstrated the immunomodulatory activity of banana inflorescence extract (HEM) on a mice model of combined allergic rhinitis and asthma syndrome (CARAS) and in human macrop...
TNF-alpha-induced microglia activation requires miR-342: impact on NF-kB signal...
Bras, JP; Bravo, J; Freitas, J; Barbosa, MA; Santos, SG; Summavielle, T; Almeida, MIGrowing evidences suggest that sustained neuroinflammation, caused by microglia overactivation, is implicated in the development and aggravation of several neurological and psychiatric disorders. In some pathological conditions, microglia produce increased levels of cytotoxic and inflammatory mediators, such as tumor necrosis factor alpha (TNF-a), which can reactivate microglia in a positive feedback mechanism....
Modulation of the in vivo inflammatory response by pro-versus anti-inflammatory...
Cunha, C; Teixeira, GQ; Ribeiro-Machado, C; Leite Pereira, C; Ferreira, JR; Molinos, M; Santos, SG; Barbosa, MA; Gonçalves, RMInflammation is central in intervertebral disc (IVD) degeneration/regeneration mechanisms, and its balance is crucial to maintain tissue homeostasis. This work investigates the modulation of local and systemic inflammatory response associated with IVD degeneration/herniation by administration of PRO-versus ANTI-inflammatory treatments. Chitosan/poly-¿-glutamic acid nanocomplexes, known as pro-inflammatory (PRO)...
Macrophages down-regulate gene expression of intervertebral disc degenerative m...
Silva, AJ; Ferreira, JR; Cunha, C; Corte-Real, JV; Bessa-Gonçalves, M; Barbosa, MA; Santos, SG; Gonçalves, RMLow back pain is a highly prevalent clinical problem and intervertebral disc (IVD) degeneration is now accepted as the major pathophysiological mechanism responsible for this condition. Accumulating evidence suggests that inflammation plays a crucial role in the progression of human IVD degeneration, with macrophages being pointed as the key immune cell players in this process since their infiltration in degene...
The two faces of tumor-associated macrophages and their clinical significance i...
Pinto, ML; Rios, E; Durães, C; Ribeiro, R; Machado, JC; Mantovani, A; Barbosa, MA; Carneiro, F; Oliveira, MJMacrophages are one of the immune populations frequently found in colorectal tumors and high macrophage infiltration has been associated with both better and worst prognosis. Importantly, according to microenvironment stimuli, macrophages may adopt different polarization profiles, specifically the pro-inflammatory or M1 and the anti-inflammatory or M2, which display distinct functions. Therefore, concomitantly ...
Long noncoding RNAs: a missing link in osteoporosis
Silva, AM; Moura, SR; Teixeira, JH; Barbosa, MA; Santos, SG; Almeida, MIOsteoporosis is a systemic disease that results in loss of bone density and increased fracture risk, particularly in the vertebrae and the hip. This condition and associated morbidity and mortality increase with population ageing. Long noncoding (lnc) RNAs are transcripts longer than 200 nucleotides that are not translated into proteins, but play important regulatory roles in transcriptional and post-transcript...
The systemic immune response to collagen-induced arthritis and the impact of bo...
Teixeira, JH; Silva, AM; Almeida, MI; Bessa-Gonçalves, M; Cunha, C; Barbosa, MA; Santos, SGRheumatoid arthritis (RA) is a systemic disease that affects the osteoarticular system, associated with bone fragility and increased risk of fractures. Herein, we aimed to characterize the systemic impact of the rat collagen-induced arthritis (CIA) model and explore its combination with femoral bone defect (FD). The impact of CIA on endogenous mesenchymal stem/stromal cells (MSC) was also investigated. CIA indu...
Genetically engineered-MSC therapies for non-unions, delayed unions and critica...
Freitas, J; Santos, SG; Gonçalves, RM; Teixeira, JH; Barbosa, MA; Almeida, MIThe normal bone regeneration process is a complex and coordinated series of events involving different cell types and molecules. However, this process is impaired in critical-size/large bone defects, with non-unions or delayed unions remaining a major clinical problem. Novel strategies are needed to aid the current therapeutic approaches. Mesenchymal stem/stromal cells (MSCs) are able to promote bone regenerati...